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10.1371/journal.pone.0094244
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DC Field | Value | Language |
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dc.contributor.author | Grigorova, Marina | - |
dc.contributor.author | Punab, Margus | - |
dc.contributor.author | Punab, Anna Maria | - |
dc.contributor.author | Poolamets, Olev | - |
dc.contributor.author | Vihljajev, Vladimir | - |
dc.contributor.author | Žilaitiene, Birute | - |
dc.contributor.author | Erenpreiss, Juris | - |
dc.contributor.author | Matulevičius, Valentinas | - |
dc.contributor.author | Laan, Maris | - |
dc.date.accessioned | 2021-08-19T07:45:01Z | - |
dc.date.available | 2021-08-19T07:45:01Z | - |
dc.date.issued | 2014-04-09 | - |
dc.identifier.citation | Grigorova , M , Punab , M , Punab , A M , Poolamets , O , Vihljajev , V , Žilaitiene , B , Erenpreiss , J , Matulevičius , V & Laan , M 2014 , ' Reproductive physiology in young men is cumulatively affected by FSH-action modulating genetic variants : FSHR -29G/A and c.2039 A/G, FSHB -211G/T ' , PLoS ONE , vol. 9 , no. 4 , e94244 . https://doi.org/10.1371/journal.pone.0094244 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6042 | - |
dc.description.abstract | Follicle-Stimulating Hormone Receptor (FSHR) -29G/A polymorphism (rs1394205) was reported to modulate gene expression and reproductive parameters in women, but data in men is limited. We aimed to bring evidence to the effect of FSHR -29G/A variants in men. In Baltic young male cohort (n = 982; Estonians, Latvians, Lithuanians; aged -0.2±2.0 years), the FSHR -29 A-allele was significantly associated with higher serum FSH (linear regression: effect 0.27 IU/L; P = 0.0019, resistant to Bonferroni correction for multiple testing) and showed a non-significant trend for association with higher LH (0.19 IU/L) and total testosterone (0.93 nmol/L), but reduced Inhibin B (-7.84 pg/mL) and total testes volume (effect -1.00 mL). Next, we extended the study and tested the effect of FSHR gene haplotypes determined by the allelic combination of FSHR -29G/A and a well-studied variant c.2039 A/G (Asn680Ser, exon 10). Among the FSHR -29A/2039G haplotype carriers (A-Ser; haplotype-based linear regression), this genetic effect was enhanced for FSH (effect 0.40 IU/L), Inhibin B (-16.57 pg/mL) and total testes volume (-2.34 mL). Finally, we estimated the total contribution of three known FSH-action modulating SNPs ( FSHB -211G/T; FSHR -29G/A, c.2039 A/G) to phenotypic variance in reproductive parameters among young men. The major FSH-action modulating SNPs explained together 2.3%, 1.4%, 1.0 and 1.1% of the measured variance in serum FSH, Inhibin B, testosterone and total testes volume, respectively. In contrast to the young male cohort, neither FSHR -29G/A nor FSHR haplotypes appeared to systematically modulate the reproductive physiology of oligozoospermic idiopathic infertile patients (n = 641, Estonians; aged 31.5±6.0 years). In summary, this is the first study showing the significant effect of FSHR -29G/A on male serum FSH level. To account for the genetic effect of known common polymorphisms modulating FSH-action, we suggest haplotype-based analysis of FSHR SNPs (FSHR -29G/A, c.2039 A/G) in combination with FSHB -211G/T testing. | en |
dc.format.extent | 735062 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | PLoS ONE | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Biochemistry,Genetics and Molecular Biology | - |
dc.subject | General Agricultural and Biological Sciences | - |
dc.subject | General | - |
dc.title | Reproductive physiology in young men is cumulatively affected by FSH-action modulating genetic variants : FSHR -29G/A and c.2039 A/G, FSHB -211G/T | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1371/journal.pone.0094244 | - |
dc.contributor.institution | Scientific Laboratory of Molecular Genetics | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84899567811&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Reproductive_Physiology_in_Young_Men_Is_Cumulatively.pdf | 717.83 kB | Adobe PDF | View/Open |
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