Please use this identifier to cite or link to this item:
10.5114/pjp.2015.53015
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Simtniece, Zane | - |
dc.contributor.author | Vanags, Andrejs | - |
dc.contributor.author | Strumfa, Ilze | - |
dc.contributor.author | Sperga, Maris | - |
dc.contributor.author | Vasko, Ervins | - |
dc.contributor.author | Prieditis, Peteris | - |
dc.contributor.author | Trapencieris, Peteris | - |
dc.contributor.author | Gardovskis, Janis | - |
dc.date.accessioned | 2021-08-12T07:40:01Z | - |
dc.date.available | 2021-08-12T07:40:01Z | - |
dc.date.issued | 2015-07-30 | - |
dc.identifier.citation | Simtniece , Z , Vanags , A , Strumfa , I , Sperga , M , Vasko , E , Prieditis , P , Trapencieris , P & Gardovskis , J 2015 , ' Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms ' , Polish Journal of Pathology , vol. 66 , no. 2 , pp. 176-194 . https://doi.org/10.5114/pjp.2015.53015 | - |
dc.identifier.issn | 1233-9687 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/5983 | - |
dc.description | Publisher Copyright: © 2015, Versalius University Medical Publisher. All rights reserved. | - |
dc.description.abstract | The study represents a comprehensive retrospective morphological and immunohistochemical profiling of pancreatic neuroendocrine neoplasms (PNENs) in order to reveal the associations between morphological and molecular parameters. The local tumour spread (T), presence of metastases in regional lymph nodes (N) and distant organs (M), tumour grade (G) and resection line status (R) by pathology findings (pTNMGR), mitotic activity, perineural, vascular and lymphatic invasion were assessed in 16 surgically resected PNENs. By immunohistochemistry, expression of Ki-67, p53, p27, p21, cyclin D1, Bcl-2, E-cadherin, CD44, vimentin, cyclooxygenase 2 (COX-2), microvascular density, and cytokeratin (CK) spectrum, along with neuroendocrine, intestinal and squamous markers were detected. Descriptive statistics, Chi-square test, Spearman’s rank correlation, Mann–Whitney and Kruskal–Wallis methods were applied; p < 0.05 was considered significant. Ki-67, CK19, p63, vimentin and COX-2 were significantly up-regulated in PNENs in comparison to benign pancreatic islets. A complex network of morphological and molecular associations was identified. Ki-67 correlated with PNEN size (p = 0.022), the World Health Organization 2004 and 2010 classification grades (p = 0.021 and p = 0.002), stage (p = 0.028) and mitotic count (p = 0.007) but among molecular markers – with CK19 (p = 0.033) and vimentin (p = 0.045). CK19 was significantly up-regulated in PNENs, having higher pT (p = 0.018), pR (p = 0.025), vascular (p = 0.020), perineural (p = 0.026) and lymphatic invasion (p = 0.043). In conclusion, proliferation activity (by Ki-67), E-cadherin, vimentin and CK19 are important molecular characteristics of PNENs due to significant associations with morphological tumour characteristics, pTNMGR and invasive growth. | en |
dc.format.extent | 19 | - |
dc.format.extent | 810683 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Polish Journal of Pathology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Cytokeratin 19 | - |
dc.subject | E-cadherin | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Pancreatic neuroendocrine neoplasm | - |
dc.subject | Vimentin | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Pathology and Forensic Medicine | - |
dc.title | Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.5114/pjp.2015.53015 | - |
dc.contributor.institution | Department of Pathology | - |
dc.contributor.institution | Department of Surgery | - |
dc.contributor.institution | Department of Radiology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84938088136&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Morphological_and_immunohistochemical_profile.pdf | 791.68 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.