Please use this identifier to cite or link to this item:
10.3390/pediatric13030054
Title: | Gallbladder Interleukins in Children with Calculous Cholecystitis |
Authors: | Deņisova, Arina Pilmane, Māra Eņģelis, Arnis Pētersons, Aigars Institute of Anatomy and Anthropology Department of Paediatric Surgery |
Keywords: | cholecystitis;gallbladder;children;interleukins;epithelium;connective tissue;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | Sep-2021 |
Citation: | Deņisova , A , Pilmane , M , Eņģelis , A & Pētersons , A 2021 , ' Gallbladder Interleukins in Children with Calculous Cholecystitis ' , Pediatric Reports , vol. 13 , no. 3 , pp. 470-482 . https://doi.org/10.3390/pediatric13030054 |
Abstract: | Calculous cholecystitis connects to inflammation and various complications. It is a common disease in the paediatric population, yet it is still uncertain how inflammation factors are involved in its morphopathogenesis. Twenty calculous cholecystitis surgery tissue samples were obtained from 20 children. As a control, seven unaffected gallbladders were used. Tissues were immunohistochemically stained for IL-1α, IL-4, IL-6, IL-7, IL-8, IL-10, and IL-17A, and the slides were inspected by light microscopy. To evaluate statistical differences and correlations between interleukins, Mann–Whitney U and Spearman’s tests were used. Statistically significant difference between patient and control gallbladder epithelium was for IL-1α and IL-17A, but connective tissue—IL-1α, IL-4, IL-6, IL-7, IL-8, and IL-17A positive structures. A strong positive correlation in patients was detected between epithelial IL-1α and IL-1α in connective tissue, epithelial IL-6 and IL-7, IL-6 and IL-17A, IL-7 and IL-10, IL-7 and IL-17A, as well as between IL-6 and IL-7, IL-7 and IL-10 in connective tissue. The increase of IL-1α, IL-4, IL-6, IL-7, IL-8 and IL-17A positive structures suggests their role in the morphopathogenesis of calculous cholecystitis. The correlations between interleukins in epithelium and in connective tissues prove that the epithelial barrier function and inflammatory response in deeper layers are sustained through intercellular signalling pathways. |
Description: | Publisher Copyright: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/pediatric13030054 |
ISSN: | 2036-749X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Gallbladder_Interleukins.pdf | 6.8 MB | Adobe PDF | View/Open |
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