Please use this identifier to cite or link to this item:
10.5588/pha.14.0041
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kuksa, Liga | - |
dc.contributor.author | Riekstina, V. | - |
dc.contributor.author | Leimane, V. | - |
dc.contributor.author | Ozere, I. | - |
dc.contributor.author | Skenders, G. | - |
dc.contributor.author | Vandenbergh, R. | - |
dc.contributor.author | Kremer, K. | - |
dc.contributor.author | Acosta, C. D. | - |
dc.contributor.author | Harries, A. D. | - |
dc.date.accessioned | 2021-07-13T13:00:01Z | - |
dc.date.available | 2021-07-13T13:00:01Z | - |
dc.date.issued | 2014-10-21 | - |
dc.identifier.citation | Kuksa , L , Riekstina , V , Leimane , V , Ozere , I , Skenders , G , Vandenbergh , R , Kremer , K , Acosta , C D & Harries , A D 2014 , ' Multi- and extensively drug-resistant tuberculosis in Latvia : Trends, characteristics and treatment outcomes ' , Public Health Action , vol. 4 , pp. S47-S53 . https://doi.org/10.5588/pha.14.0041 | - |
dc.identifier.issn | 2220-8372 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/5870 | - |
dc.description | Publisher Copyright: © 2014, The Union. | - |
dc.description.abstract | Setting: Drug-resistant tuberculosis (TB) is an important public health problem in Latvia. Objective: To document trends, characteristics and treatment outcomes of registered patients with multidrug- resistant (MDR-) and extensively drug-resistant (XDR-) TB in Latvia from 2000 to 2010. Design: A retrospective national cohort study. Results: Of 1779 patients, 1646 (92%) had MDR- and 133 (8%) XDR-TB. Over 11 years, the proportion of XDR-TB among MDR-TB patients increased from 2% to 18%. Compared to MDR-TB patients, those with XDR-TB were significantly more likely to have failed MDR-TB treatment (OR 8.4, 95%CI 4.3–16.2), have human immunodeficiency virus infection (OR 3.2, 95%CI 1.8–5.7), be illegal drug users (OR 5.7, 95%CI 2.6–11.6) or have had contact with MDR-TB patients (OR 1.9, 95%CI 1.3– 2.8). Cure rates for XDR-TB were 50%. Compared with MDR-TB patients, those with XDR-TB had a higher risk of treatment failure (29% vs. 8%, respectively, P < 0.001). Unfavourable treatment outcomes were significantly associated with being male; having smear-positive disease; pulmonary cavities; failure, default or relapse after previous MDR-TB treatment; and a history of incarceration. Conclusion: More MDR-TB in Latvia is now also XDR-TB. This study identified several risk factors for XDR-TB and, for unfavourable treatment outcomes, highlighting the importance of early diagnosis and appropriate management of MDR-/XDR-TB. | en |
dc.format.extent | 270985 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Public Health Action | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Europe | - |
dc.subject | Latvia | - |
dc.subject | Operational research | - |
dc.subject | SORT IT | - |
dc.subject | XDR-TB | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Health Policy | - |
dc.subject | Public Health, Environmental and Occupational Health | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Multi- and extensively drug-resistant tuberculosis in Latvia : Trends, characteristics and treatment outcomes | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.5588/pha.14.0041 | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84940459640&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Multi_and_extensively_drug_resistant_tuberculosis.pdf | 264.63 kB | Adobe PDF | View/Open |
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