Please use this identifier to cite or link to this item:
10.1186/1897-4287-4-1-48
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DC Field | Value | Language |
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dc.contributor.author | Irmejs, Arvids | - |
dc.contributor.author | Miklasevics, Edvins | - |
dc.contributor.author | Boroschenko, Viktors | - |
dc.contributor.author | Gardovskis, Andris | - |
dc.contributor.author | Vanags, Andrejs | - |
dc.contributor.author | Melbarde-Gorkusa, Inga | - |
dc.contributor.author | Bitina, Marianna | - |
dc.contributor.author | Suchy, Janina | - |
dc.contributor.author | Gardovskis, Janis | - |
dc.date.accessioned | 2021-07-13T07:55:01Z | - |
dc.date.available | 2021-07-13T07:55:01Z | - |
dc.date.issued | 2006-03-15 | - |
dc.identifier.citation | Irmejs , A , Miklasevics , E , Boroschenko , V , Gardovskis , A , Vanags , A , Melbarde-Gorkusa , I , Bitina , M , Suchy , J & Gardovskis , J 2006 , ' Pilot study on low penetrance breast and colorectal cancer predisposition markers in Latvia ' , Hereditary cancer in clinical practice , vol. 4 , no. 1 , pp. 48-51 . https://doi.org/10.1186/1897-4287-4-1-48 | - |
dc.identifier.issn | 1731-2302 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/5863 | - |
dc.description.abstract | Introduction: It has not been established whether CHEK2 and NOD2 variants are present in Latvia and whether inherited variation in these genes influences cancer risk in this population. Aim of the study: To evaluate the role of CHEK2 and NOD2 mutations in breast and colorectal cancers in the population of Latvia. Materials and methods: Peripheral venous blood samples were collected from 185 breast cancer and 235 colorectal cancer consecutive hospital-based cases from 11/2003 to 06/2005. The population control group included blood samples from the clamped distal part of the umbilical cord from 978 consecutive anonymous newborns born between 03/2005 and 08/2005. All cases and controls were tested for the presence of NOD2 3020insC mutation and CHEK2 I157T mutation. Results: NOD2 3020insC was present in 7.7% (18/235) of CRC cancers, in 9.2% (17/185) of breast cancers and in 7.7% (75/974) of controls. CHEK2 I157T variant was found in 7.6% (14/185) of breast cancer cases, 10.2% (24/235) of colon cancer cases and in 6.4% (63/978) of population controls. NOD2 3020insC variant was associated with increased risk of breast cancer (OR=2.5, p<0.05) for cases diagnosed at age between 51 and 60 years. CHEK2 I157T variant was associated with increased risk of colorectal cancer (OR=1.7, p<0.05) with the highest OR=2.0 for cases diagnosed at age >70 yrs. Conclusions: NOD2 3020insC and CHEK2 I157T variants may be associated with increased risk of colorectal and breast cancers in Latvia. | en |
dc.format.extent | 4 | - |
dc.format.extent | 110116 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Hereditary cancer in clinical practice | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Breast and colorectal | - |
dc.subject | Cancer | - |
dc.subject | Markers | - |
dc.subject | Predisposition | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Oncology | - |
dc.subject | Genetics(clinical) | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Pilot study on low penetrance breast and colorectal cancer predisposition markers in Latvia | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1186/1897-4287-4-1-48 | - |
dc.contributor.institution | Hereditary Cancer Research Department | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=33645732203&partnerID=8YFLogxK | - |
dc.identifier.url | https://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-4-1-48 | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Pilot_Study_on_Low_Penetrance_Breast_and_Colorectal_Cancer_Predisposition.pdf | 107.54 kB | Adobe PDF | View/Open |
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