Please use this identifier to cite or link to this item: 10.3390/polym13121996
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dc.contributor.authorPandey, Aditi-
dc.contributor.authorYang, Tzu Sen-
dc.contributor.authorCheng, Shu Lien-
dc.contributor.authorHuang, Ching Shuan-
dc.contributor.authorBrangule, Agnese-
dc.contributor.authorKareiva, Aivaras-
dc.contributor.authorYang, Jen Chang-
dc.date.accessioned2021-07-06T08:55:02Z-
dc.date.available2021-07-06T08:55:02Z-
dc.date.issued2021-06-18-
dc.identifier.citationPandey , A , Yang , T S , Cheng , S L , Huang , C S , Brangule , A , Kareiva , A & Yang , J C 2021 , ' A novel one-pot synthesis and characterization of silk fibroin/α-calcium sulfate hemihydrate for bone regeneration ' , Polymers , vol. 13 , no. 12 , 1996 . https://doi.org/10.3390/polym13121996-
dc.identifier.issn2073-4360-
dc.identifier.otherunpaywall: 10.3390/polym13121996-
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5834-
dc.descriptionFunding Information: Funding: Support for this work was provided by the Ministry of Science and Technology, Taiwan MOST 109-2224-E-038-002. The APC was funded by MOST. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.-
dc.description.abstractThis study aims to fabricate silk fibroin/calcium sulfate (SF/CS) composites by one-pot synthesis for bone regeneration applications. The SF was harvested from degummed silkworm cocoons, dissolved in a solvent system comprising of calcium chloride:ethanol:water (1:2:8), and then mixed with a stoichiometric amount of sodium sulfate to prepare various SF/CS composites. The crystal pattern, glass transition temperature, and chemical composition of SF/CS samples were analyzed by XRD, DSC, and FTIR, respectively. These characterizations revealed the successful synthesis of pure calcium sulfate dihydrate (CSD) and calcium sulfate hemihydrate (CSH) when it was combined with SF. The thermal analysis through DSC indicated molecular-level interaction between the SF and CS. The FTIR deconvolution spectra demonstrated an increment in the β-sheet content by increasing CS content in the composites. The investigation into the morphology of the composites using SEM revealed the formation of plate-like dihydrate in the pure CS sample, while rod-like structures of α-CSH surrounded by SF in the composites were observed. The compressive strength of the hydrated 10 and 20% SF-incorporated CSH composites portrayed more than a twofold enhancement (statistically significant) in comparison to that of the pure CS samples. Reduced compressive strength was observed upon further increasing the SF content, possibly due to SF agglomeration that restricted its uniform distribution. Therefore, the one-pot synthesized SF/CS composites demonstrated suitable chemical, thermal, and morphological properties. However, additional biological analysis of its potential use as bone substitutes is required.en
dc.format.extent20293714-
dc.language.isoeng-
dc.relation.ispartofPolymers-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectCalcium sulfate hemihydrate-
dc.subjectSilk fibroin-
dc.subject1.4 Chemical sciences-
dc.subject3.1 Basic medicine-
dc.subject3.4 Medical biotechnology-
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database-
dc.subjectGeneral Chemistry-
dc.subjectPolymers and Plastics-
dc.titleA novel one-pot synthesis and characterization of silk fibroin/α-calcium sulfate hemihydrate for bone regenerationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article-
dc.identifier.doi10.3390/polym13121996-
dc.contributor.institutionDepartment of Pharmaceutical Chemistry-
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85108712768&partnerID=8YFLogxK-
dc.description.statusPeer reviewed-
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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