Please use this identifier to cite or link to this item:
10.3390/cells10030621
Title: | Cancer Stem Cells : Significance in Origin, Pathogenesis and Treatment of Glioblastoma |
Authors: | Biserova, Karina Jakovlevs, Arvids Uljanovs, Romans Strumfa, Ilze Residency Unit Department of Pathology |
Keywords: | cancer;cancer stem cells;glioblastoma;glioma;glioma stem cells;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine;SDG 3 - Good Health and Well-being |
Issue Date: | 11-Mar-2021 |
Citation: | Biserova , K , Jakovlevs , A , Uljanovs , R & Strumfa , I 2021 , ' Cancer Stem Cells : Significance in Origin, Pathogenesis and Treatment of Glioblastoma ' , Cells , vol. 10 , no. 3 , 621 . https://doi.org/10.3390/cells10030621 |
Abstract: | Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies. CSCs have attracted remarkable research interest due to their role in tumor resistance to chemotherapy and radiation treatment as well as recurrence. Extensive research has been devoted to the role of CSCs in glioblastoma multiforme (GBM), the most common primary brain tumor in adults, which is characterized by a dismal prognosis because of its aggressive course and poor response to treatment. The aim of the current paper is to provide an overview of current knowledge on the role of cancer stem cells in the pathogenesis and treatment resistance of glioblastoma. The six regulatory mechanisms of glioma stem cells (GSCs)-tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics-are reviewed. The molecular markers used to identify GSCs are described. The role of GSCs in the treatment resistance of glioblastoma is reviewed, along with future treatment options targeting GSCs. Stem cells of glioblastoma thus represent both a driving mechanism of major treatment difficulties and a possible target for more effective future approaches. |
Description: | Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/cells10030621 |
ISSN: | 2073-4409 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Cancer_Stem_Cells.pdf | 2.41 MB | Adobe PDF | View/Open |
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