Cancer Stem Cells : Significance in Origin, Pathogenesis and Treatment of Glioblastoma

Simple item page
dc.contributor.authorBiserova, Karina
dc.contributor.authorJakovlevs, Arvids
dc.contributor.authorUljanovs, Romans
dc.contributor.authorStrumfa, Ilze
dc.contributor.institutionResidency Unit
dc.contributor.institutionDepartment of Pathology
dc.date.accessioned2021-07-01T14:25:01Z
dc.date.available2021-07-01T14:25:01Z
dc.date.issued2021-03-11
dc.descriptionPublisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractCancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies. CSCs have attracted remarkable research interest due to their role in tumor resistance to chemotherapy and radiation treatment as well as recurrence. Extensive research has been devoted to the role of CSCs in glioblastoma multiforme (GBM), the most common primary brain tumor in adults, which is characterized by a dismal prognosis because of its aggressive course and poor response to treatment. The aim of the current paper is to provide an overview of current knowledge on the role of cancer stem cells in the pathogenesis and treatment resistance of glioblastoma. The six regulatory mechanisms of glioma stem cells (GSCs)-tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics-are reviewed. The molecular markers used to identify GSCs are described. The role of GSCs in the treatment resistance of glioblastoma is reviewed, along with future treatment options targeting GSCs. Stem cells of glioblastoma thus represent both a driving mechanism of major treatment difficulties and a possible target for more effective future approaches.en
dc.description.statusPeer reviewed
dc.format.extent20
dc.format.extent2469466
dc.identifier.citationBiserova, K, Jakovlevs, A, Uljanovs, R & Strumfa, I 2021, 'Cancer Stem Cells : Significance in Origin, Pathogenesis and Treatment of Glioblastoma', Cells, vol. 10, no. 3, 621. https://doi.org/10.3390/cells10030621
dc.identifier.doi10.3390/cells10030621
dc.identifier.issn2073-4409
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5795
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85103863347&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCells
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcancer
dc.subjectcancer stem cells
dc.subjectglioblastoma
dc.subjectglioma
dc.subjectglioma stem cells
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCancer Stem Cells : Significance in Origin, Pathogenesis and Treatment of Glioblastomaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Cancer_Stem_Cells.pdf
Size:
2.36 MB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure