Please use this identifier to cite or link to this item:
10.1515/prolas-2015-0044
Title: | Different Cytokine Profiles in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis |
Authors: | Zviedre, Astra Eņģelis, Arnis Tretjakovs, Pēteris Jurka, Antra Zīle, Irisa Pētersons, Aigars Department of Paediatric Surgery Department of Human Physiology and Biochemistry Department of Public Health and Epidemiology |
Keywords: | appendicitis;cytokines;diagnosis;mesenteric lymphadenitis;1.6 Biological sciences;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General |
Issue Date: | 1-Dec-2015 |
Citation: | Zviedre , A , Eņģelis , A , Tretjakovs , P , Jurka , A , Zīle , I & Pētersons , A 2015 , ' Different Cytokine Profiles in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 69 , no. 6 , pp. 283-289 . https://doi.org/10.1515/prolas-2015-0044 |
Abstract: | The aim of this study was to investigate the role of serum cytokines in the diagnosis of acute appendicitis (AA) and acute mesenteric lymphadenitis (AML). Data were collected prospectively on 7 to 18 year old children (October 2010 - October 2013): 31 patients with AA, 26 patients with AML, and 17 patients with elective non-inflammatory surgical disease were selected as controls. Serum levels of IL-10, IL-12(p70), IL-1β, IL-4, IL-6, IL-8, IL-17, MCP-1, EGF, TNF-α were measured. Patients with AA had significantly increased serum levels of IL-6(1) (z = -3.72; p = 0.0002) and IL-10(1) (z = -2.81; p = 0.005) compared to AML before any treatment. The consecutive measurements of MCP-1 in serum demonstrated a significant difference within 72 hours in the AA group (Wilks' Lambda test 0.80; F(2;29) = 3.5; p = 0.04) and also in the AML group (Wilks' Lambda test 0.70; F(2;24) = 5.0; p = 0.01). The increased values of IL-6 and IL-10 were the most reliable cytokines one hour before surgical intervention for patients with AA. MCP-1 values changed significantly within 72 hours after patient hospitalisation but did not differ between the groups, and could not be a helpful serum biomarker in distinguishing patients with AA and AML. |
DOI: | 10.1515/prolas-2015-0044 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Different_cytokine_profiles_in_children.pdf | 282.69 kB | Adobe PDF | View/Open |
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