Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0030
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Čistjakovs, Maksims | - |
dc.contributor.author | Sultanova, Alina | - |
dc.contributor.author | Jermakova, Olga | - |
dc.contributor.author | Čapenko, Svetlana | - |
dc.contributor.author | Lesiņa-Korne, Baiba | - |
dc.contributor.author | Rozentāls, Rafails | - |
dc.contributor.author | Murovska, Modra | - |
dc.contributor.author | Ziediņa, Ieva | - |
dc.date.accessioned | 2021-06-21T06:45:01Z | - |
dc.date.available | 2021-06-21T06:45:01Z | - |
dc.date.issued | 2016-08-01 | - |
dc.identifier.citation | Čistjakovs , M , Sultanova , A , Jermakova , O , Čapenko , S , Lesiņa-Korne , B , Rozentāls , R , Murovska , M & Ziediņa , I 2016 , ' High-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipients ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 193-197 . https://doi.org/10.1515/prolas-2016-0030 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/5334 | - |
dc.description | Publisher Copyright: © 2016 by Maksims Cistjakovs. | - |
dc.description.abstract | Kidney transplant recipients have higher incidence of human papillomavirus (HPV)-related malignancies, but studies on the natural history of HPV infection are insufficient, especially regarding in male recipients. The aim of this study was to evaluate the course of high-risk HPV (HR-HPV) infection after kidney allograft transplantation in male recipients: to estimate frequency and activity of HR-HPV infection under immune system suppression. Twenty male renal recipients (age 20-68) were enrolled in this investigation and examined in dynamics. Peripheral EDTA-blood samples and urine samples were collected from each patient 2 weeks, 6 months and 12 months after transplantation. Polymerase chain reaction (PCR) with consensus primers was used for initial detection of high range HPV types, a commercial qPCR kit for detection of HR-HPV load in urine samples and ELISA for detection of serum IgG class antibodies to HR-HPV L1-capsid protein. Overall, combining molecular (HR-HPV genomic sequences detected by real-time PCR) and serological studies (IgG class antibodies to HR-HPV L1-capsids' protein), high frequency of HRHPV infection among male kidney transplant recipients (9/20; 45%) was showed. However, the majority of HR-HPV positive recipients (7/9; 78%) showed signs of infection clearance. It means that, despite the applied immune suppressive therapy, the host's immune system is capable of dealing with HR-HPV infection up to the 12th month after transplantation. However, the sample size should be increased to enable through statistical analysis before final conclusions are made. | en |
dc.format.extent | 5 | - |
dc.format.extent | 72769 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | HR-HPV | - |
dc.subject | kidney transplant recipients | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.title | High-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipients | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1515/prolas-2016-0030 | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.contributor.institution | Department of Internal Diseases | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84983420831&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
High_Risk_Human_Papillomavirus_Infection_in_Latvian_Male_Kidney_Transplant_Recipients.pdf | 71.06 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.