Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0030
Title: | High-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipients |
Authors: | Čistjakovs, Maksims Sultanova, Alina Jermakova, Olga Čapenko, Svetlana Lesiņa-Korne, Baiba Rozentāls, Rafails Murovska, Modra Ziediņa, Ieva Institute of Microbiology and Virology Department of Internal Diseases |
Keywords: | HR-HPV;kidney transplant recipients;3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General |
Issue Date: | 1-Aug-2016 |
Citation: | Čistjakovs , M , Sultanova , A , Jermakova , O , Čapenko , S , Lesiņa-Korne , B , Rozentāls , R , Murovska , M & Ziediņa , I 2016 , ' High-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipients ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 193-197 . https://doi.org/10.1515/prolas-2016-0030 |
Abstract: | Kidney transplant recipients have higher incidence of human papillomavirus (HPV)-related malignancies, but studies on the natural history of HPV infection are insufficient, especially regarding in male recipients. The aim of this study was to evaluate the course of high-risk HPV (HR-HPV) infection after kidney allograft transplantation in male recipients: to estimate frequency and activity of HR-HPV infection under immune system suppression. Twenty male renal recipients (age 20-68) were enrolled in this investigation and examined in dynamics. Peripheral EDTA-blood samples and urine samples were collected from each patient 2 weeks, 6 months and 12 months after transplantation. Polymerase chain reaction (PCR) with consensus primers was used for initial detection of high range HPV types, a commercial qPCR kit for detection of HR-HPV load in urine samples and ELISA for detection of serum IgG class antibodies to HR-HPV L1-capsid protein. Overall, combining molecular (HR-HPV genomic sequences detected by real-time PCR) and serological studies (IgG class antibodies to HR-HPV L1-capsids' protein), high frequency of HRHPV infection among male kidney transplant recipients (9/20; 45%) was showed. However, the majority of HR-HPV positive recipients (7/9; 78%) showed signs of infection clearance. It means that, despite the applied immune suppressive therapy, the host's immune system is capable of dealing with HR-HPV infection up to the 12th month after transplantation. However, the sample size should be increased to enable through statistical analysis before final conclusions are made. |
Description: | Publisher Copyright: © 2016 by Maksims Cistjakovs. |
DOI: | 10.1515/prolas-2016-0030 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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High_Risk_Human_Papillomavirus_Infection_in_Latvian_Male_Kidney_Transplant_Recipients.pdf | 71.06 kB | Adobe PDF | View/Open |
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