High-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipients

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dc.contributor.authorČistjakovs, Maksims
dc.contributor.authorSultanova, Alina
dc.contributor.authorJermakova, Olga
dc.contributor.authorČapenko, Svetlana
dc.contributor.authorLesiņa-Korne, Baiba
dc.contributor.authorRozentāls, Rafails
dc.contributor.authorMurovska, Modra
dc.contributor.authorZiediņa, Ieva
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2021-06-21T06:45:01Z
dc.date.available2021-06-21T06:45:01Z
dc.date.issued2016-08-01
dc.descriptionPublisher Copyright: © 2016 by Maksims Cistjakovs.
dc.description.abstractKidney transplant recipients have higher incidence of human papillomavirus (HPV)-related malignancies, but studies on the natural history of HPV infection are insufficient, especially regarding in male recipients. The aim of this study was to evaluate the course of high-risk HPV (HR-HPV) infection after kidney allograft transplantation in male recipients: to estimate frequency and activity of HR-HPV infection under immune system suppression. Twenty male renal recipients (age 20-68) were enrolled in this investigation and examined in dynamics. Peripheral EDTA-blood samples and urine samples were collected from each patient 2 weeks, 6 months and 12 months after transplantation. Polymerase chain reaction (PCR) with consensus primers was used for initial detection of high range HPV types, a commercial qPCR kit for detection of HR-HPV load in urine samples and ELISA for detection of serum IgG class antibodies to HR-HPV L1-capsid protein. Overall, combining molecular (HR-HPV genomic sequences detected by real-time PCR) and serological studies (IgG class antibodies to HR-HPV L1-capsids' protein), high frequency of HRHPV infection among male kidney transplant recipients (9/20; 45%) was showed. However, the majority of HR-HPV positive recipients (7/9; 78%) showed signs of infection clearance. It means that, despite the applied immune suppressive therapy, the host's immune system is capable of dealing with HR-HPV infection up to the 12th month after transplantation. However, the sample size should be increased to enable through statistical analysis before final conclusions are made.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent72769
dc.identifier.citationČistjakovs, M, Sultanova, A, Jermakova, O, Čapenko, S, Lesiņa-Korne, B, Rozentāls, R, Murovska, M & Ziediņa, I 2016, 'High-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipients', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 70, no. 4, pp. 193-197. https://doi.org/10.1515/prolas-2016-0030
dc.identifier.doi10.1515/prolas-2016-0030
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5334
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84983420831&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHR-HPV
dc.subjectkidney transplant recipients
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleHigh-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipientsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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