Please use this identifier to cite or link to this item:
10.1155/2016/8910396
Title: | Oxidative Stress during HIV Infection : Mechanisms and Consequences |
Authors: | Ivanov, Alexander V. Valuev-Elliston, Vladimir T. Ivanova, Olga N. Kochetkov, Sergey N. Starodubova, Elizaveta S. Bartosch, Birke Isaguliants, Maria G. Rīga Stradiņš University |
Keywords: | 1.6 Biological sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Biochemistry;Ageing;Cell Biology;SDG 3 - Good Health and Well-being |
Issue Date: | 2016 |
Citation: | Ivanov , A V , Valuev-Elliston , V T , Ivanova , O N , Kochetkov , S N , Starodubova , E S , Bartosch , B & Isaguliants , M G 2016 , ' Oxidative Stress during HIV Infection : Mechanisms and Consequences ' , Oxidative Medicine and Cellular Longevity , vol. 2016 , no. S , 8910396 . https://doi.org/10.1155/2016/8910396 |
Abstract: | It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a variety of natural processes in cells. If increased to levels which cannot be neutralized by the defense mechanisms, they damage biological molecules, alter their functions, and also act as signaling molecules thus generating a spectrum of pathologies. In this review, we summarize current data on oxidative stress markers associated with human immunodeficiency virus type-1 (HIV-1) infection, analyze mechanisms by which this virus triggers massive ROS production, and describe the status of various defense mechanisms of the infected host cell. In addition, we have scrutinized scarce data on the effect of ROS on HIV-1 replication. Finally, we present current state of knowledge on the redox alterations as crucial factors of HIV-1 pathogenicity, such as neurotoxicity and dementia, exhaustion of CD4+/CD8+ T-cells, predisposition to lung infections, and certain side effects of the antiretroviral therapy, and compare them to the pathologies associated with the nitrosative stress. |
Description: | Publisher Copyright: © 2016 Alexander V. Ivanov et al. |
DOI: | 10.1155/2016/8910396 |
ISSN: | 1942-0900 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Oxidative_Stress_during_HIV_Infection.pdf | 1.76 MB | Adobe PDF | View/Open |
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