Please use this identifier to cite or link to this item:
10.3390/v13061008
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lifsics, Andrejs | - |
dc.contributor.author | Groma, Valerija | - |
dc.contributor.author | Cistjakovs, Maksims | - |
dc.contributor.author | Skuja, Sandra | - |
dc.contributor.author | Deksnis, Renars | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2021-06-13T08:50:01Z | - |
dc.date.available | 2021-06-13T08:50:01Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.citation | Lifsics , A , Groma , V , Cistjakovs , M , Skuja , S , Deksnis , R & Murovska , M 2021 , ' Identification of High-Risk Human Papillomavirus DNA, p16, and E6/E7 Oncoproteins in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas ' , Viruses , vol. 13 , no. 6 , 1008 . https://doi.org/10.3390/v13061008 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4935 | - |
dc.description | Funding Information: The authors would like to thank the Riga Stradi?? University Department of Doctoral studies for reagents and publishing support. We would also like to thank Elza Rate, MD at the Department of Head and Neck Surgery, Oncology Centre of Latvia, for additional support with the collection of some tumor specimens. We are grateful to Simons Svirskis for his valuable help with statistical analysis. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.abstract | Human papillomavirus (HPV) was proven to play a significant role in cancer development in the oropharynx. However, its role in the development of laryngeal (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) remains to be clarified. High-risk HPV (HR-HPV) viral proteins E6 and E7 are considered to be pertinent to HPV-related carcinogenesis. Hence, our aim was to estimate LSCC and HPSCC for HR-HPV DNA, p16, and E6/E7 oncoprotein status by using molecular virology and immunohistochemistry methods. The prevalence of HPV16 infection was 22/41 (53.7%) and 20/31 (64.5%) for LSCC and HPSCC, accordingly. The majority of HPV16+ tumor samples were stage III or IV. In most samples, the presence of either HPV16 E6 or HPV16 E7 viral protein in dysplastic or tumor cells was confirmed using immunohistochemistry. Our results suggest a high prevalence of HPV16 as a primary HR-HPV type in LSCC and HPSCC. The lack of HPV E6/E7 oncoproteins in some tumor samples may suggest either the absence of viral integration or the presence of other mechanisms of tumorigenesis. The utilization of p16 IHC as a surrogate marker of HR-HPV infection is impractical in LSCC and HPSCC. | en |
dc.format.extent | 17 | - |
dc.format.extent | 7297956 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Viruses | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | HPV | - |
dc.subject | larynx | - |
dc.subject | hypopharynx | - |
dc.subject | PCR | - |
dc.subject | squamous cell carcinoma | - |
dc.subject | immunohistochemistry | - |
dc.subject | P16 Regulatory protein | - |
dc.subject | E6/E7 viral oncoproteins | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Identification of High-Risk Human Papillomavirus DNA, p16, and E6/E7 Oncoproteins in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/v13061008 | - |
dc.contributor.institution | Department of Otorhinolaryngology | - |
dc.contributor.institution | Institute of Anatomy and Anthropology | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85107442330&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Identification_of_High_risk_Human.pdf | 7.13 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.