Please use this identifier to cite or link to this item:
10.2478/prolas-2018-0066
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DC Field | Value | Language |
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dc.contributor.author | Gončars, Valdis | - |
dc.contributor.author | Kalnbērzs, Konstantīns | - |
dc.contributor.author | Jākobsons, Ērks | - |
dc.contributor.author | Briede, Ieva | - |
dc.contributor.author | Blums, Kristaps | - |
dc.contributor.author | Ērglis, Kristaps | - |
dc.contributor.author | Ērglis, Mārtiņš | - |
dc.contributor.author | Patetko, Liene | - |
dc.contributor.author | Muižnieks, Indriķis | - |
dc.contributor.author | Ērglis, Andrejs | - |
dc.date.accessioned | 2021-06-11T12:25:01Z | - |
dc.date.available | 2021-06-11T12:25:01Z | - |
dc.date.issued | 2018-08-01 | - |
dc.identifier.citation | Gončars , V , Kalnbērzs , K , Jākobsons , Ē , Briede , I , Blums , K , Ērglis , K , Ērglis , M , Patetko , L , Muižnieks , I & Ērglis , A 2018 , ' New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 72 , no. 4 , pp. 207-215 . https://doi.org/10.2478/prolas-2018-0066 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4916 | - |
dc.description | Publisher Copyright: © 2018 Valdis Gončars et al., published by Sciendo 2018. | - |
dc.description.abstract | The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II-III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were observed after the bone marrow derived mononuclear cells (BM-MNC) injection. At the end point of the follow up all score results had improved, compared to those at to the starting point. 65% of patients maintained minimal perceptible clinical improvement of the score results. The Whole Organ Magnetic Resonance Imaging Score showed improvement from 44.31 to 42.93 points (p < 0.05) during a 6-7 month period. Comparing score results to the control group, a statistically significant (p < 0.05) improvement in the KOOS pain subscale score at the 6 and 12 months was observed in the mononuclear cell group. BM-MNC injection leads to a decrease of knee OA symptoms and slows changes in structure of the degenerative joint tissue. | en |
dc.format.extent | 9 | - |
dc.format.extent | 1702093 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | bone marrow mononuclear cells | - |
dc.subject | hyaluronic acid | - |
dc.subject | knee osteoarthritis | - |
dc.subject | mesenchymal stem cells | - |
dc.subject | regenerative therapy | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.title | New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2478/prolas-2018-0066 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85064158087&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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New_Modalities_in_Knee_Osteoarthritis_Treatment.pdf | 1.66 MB | Adobe PDF | View/Open![]() |
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