Please use this identifier to cite or link to this item:
10.2478/prolas-2018-0066
Title: | New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells |
Authors: | Gončars, Valdis Kalnbērzs, Konstantīns Jākobsons, Ērks Briede, Ieva Blums, Kristaps Ērglis, Kristaps Ērglis, Mārtiņš Patetko, Liene Muižnieks, Indriķis Ērglis, Andrejs |
Keywords: | bone marrow mononuclear cells;hyaluronic acid;knee osteoarthritis;mesenchymal stem cells;regenerative therapy;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General |
Issue Date: | 1-Aug-2018 |
Citation: | Gončars , V , Kalnbērzs , K , Jākobsons , Ē , Briede , I , Blums , K , Ērglis , K , Ērglis , M , Patetko , L , Muižnieks , I & Ērglis , A 2018 , ' New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 72 , no. 4 , pp. 207-215 . https://doi.org/10.2478/prolas-2018-0066 |
Abstract: | The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II-III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were observed after the bone marrow derived mononuclear cells (BM-MNC) injection. At the end point of the follow up all score results had improved, compared to those at to the starting point. 65% of patients maintained minimal perceptible clinical improvement of the score results. The Whole Organ Magnetic Resonance Imaging Score showed improvement from 44.31 to 42.93 points (p < 0.05) during a 6-7 month period. Comparing score results to the control group, a statistically significant (p < 0.05) improvement in the KOOS pain subscale score at the 6 and 12 months was observed in the mononuclear cell group. BM-MNC injection leads to a decrease of knee OA symptoms and slows changes in structure of the degenerative joint tissue. |
Description: | Publisher Copyright: © 2018 Valdis Gončars et al., published by Sciendo 2018. |
DOI: | 10.2478/prolas-2018-0066 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
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New_Modalities_in_Knee_Osteoarthritis_Treatment.pdf | 1.66 MB | Adobe PDF | View/Open![]() |
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