New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells

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dc.contributor.authorGončars, Valdis
dc.contributor.authorKalnbērzs, Konstantīns
dc.contributor.authorJākobsons, Ērks
dc.contributor.authorBriede, Ieva
dc.contributor.authorBlums, Kristaps
dc.contributor.authorĒrglis, Kristaps
dc.contributor.authorĒrglis, Mārtiņš
dc.contributor.authorPatetko, Liene
dc.contributor.authorMuižnieks, Indriķis
dc.contributor.authorĒrglis, Andrejs
dc.date.accessioned2021-06-11T12:25:01Z
dc.date.available2021-06-11T12:25:01Z
dc.date.issued2018-08-01
dc.descriptionPublisher Copyright: © 2018 Valdis Gončars et al., published by Sciendo 2018.
dc.description.abstractThe clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II-III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were observed after the bone marrow derived mononuclear cells (BM-MNC) injection. At the end point of the follow up all score results had improved, compared to those at to the starting point. 65% of patients maintained minimal perceptible clinical improvement of the score results. The Whole Organ Magnetic Resonance Imaging Score showed improvement from 44.31 to 42.93 points (p < 0.05) during a 6-7 month period. Comparing score results to the control group, a statistically significant (p < 0.05) improvement in the KOOS pain subscale score at the 6 and 12 months was observed in the mononuclear cell group. BM-MNC injection leads to a decrease of knee OA symptoms and slows changes in structure of the degenerative joint tissue.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent1702093
dc.identifier.citationGončars, V, Kalnbērzs, K, Jākobsons, Ē, Briede, I, Blums, K, Ērglis, K, Ērglis, M, Patetko, L, Muižnieks, I & Ērglis, A 2018, 'New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 72, no. 4, pp. 207-215. https://doi.org/10.2478/prolas-2018-0066
dc.identifier.doi10.2478/prolas-2018-0066
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4916
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85064158087&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbone marrow mononuclear cells
dc.subjecthyaluronic acid
dc.subjectknee osteoarthritis
dc.subjectmesenchymal stem cells
dc.subjectregenerative therapy
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleNew Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cellsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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