Please use this identifier to cite or link to this item:
10.1111/sji.12696
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Nikulshin, Sergey | - |
dc.contributor.author | Kundzina, Linda | - |
dc.contributor.author | Tolstikova, Iveta | - |
dc.contributor.author | Gravele, Dagne | - |
dc.contributor.author | Prokofjeva, Tatjana | - |
dc.contributor.author | Gardovska, Dace | - |
dc.date.accessioned | 2021-06-11T09:45:01Z | - |
dc.date.available | 2021-06-11T09:45:01Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | Nikulshin , S , Kundzina , L , Tolstikova , I , Gravele , D , Prokofjeva , T & Gardovska , D 2018 , ' Significant age- and gender-related variability of main lymphocyte subsets in paediatric patients : Latvian data ' , Scandinavian Journal of Immunology , vol. 88 , no. 2 , e12696 . https://doi.org/10.1111/sji.12696 | - |
dc.identifier.issn | 0300-9475 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4908 | - |
dc.description | Publisher Copyright: 2018 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Foundation for the Scandinavian Journal of Immunology. | - |
dc.description.abstract | Age- and gender-related variability of main lymphocyte subsets (T, B and NK cell absolute counts and percentages from Ly; T4, T8 and DN cell absolute counts and percentages from lymphocytes and from T cells; T4:T8 and T:B ratios) was studied in a large cohort of paediatric patients (2 days-17 years) at yearly intervals. A total of 4128 six-color TBNK tests performed on BD FACSCanto II flow cytometer were assessed; patients with immune deficiencies and tumours were not included. The study revealed significant age- and gender-related changes in all subsets. Absolute counts of T, B, T4 cells dropped from neonates to adolescents, decrease in T8 and NK cells was milder; relative count of T cells increased with age and that of B cells decreased; T4:T8 ratio went down and T:B ratio grew. Total T, T4 cells and T4:T8 ratio were significantly higher in girls, while T8, NK and DN cells were significantly higher in boys; significantly higher relative and absolute B cell counts in boys appeared in adolescence. We compared our results with reference values for healthy children (Tosato et al, Cytometry A. 2015;87:81); there was a good concordance, except for DN cells. Advantages of using patient cohort instead of healthy children as reference, possibilities for adjusting age- and gender-specific reference ranges and potential international data pooling are discussed. | en |
dc.format.extent | 331566 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Scandinavian Journal of Immunology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Immunology | - |
dc.title | Significant age- and gender-related variability of main lymphocyte subsets in paediatric patients : Latvian data | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1111/sji.12696 | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85050290434&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Significant_age_and_gender_related_variability_of_main.pdf | 323.79 kB | Adobe PDF | View/Open |
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