Please use this identifier to cite or link to this item:
10.3390/medicina48060047
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DC Field | Value | Language |
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dc.contributor.author | Vanags, Andrejs | - |
dc.contributor.author | Štrumfa, Ilze | - |
dc.contributor.author | Gardovskis, Andris | - |
dc.contributor.author | Aboliņs, Arnis | - |
dc.contributor.author | Simtniece, Zane | - |
dc.contributor.author | Trofimovičs, Genadijs | - |
dc.contributor.author | Gardovskis, Janis | - |
dc.date.accessioned | 2021-06-10T07:45:01Z | - |
dc.date.available | 2021-06-10T07:45:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Vanags , A , Štrumfa , I , Gardovskis , A , Aboliņs , A , Simtniece , Z , Trofimovičs , G & Gardovskis , J 2012 , ' The first evidence of hereditary and familial gastric cancer in Latvia : Implications for prevention ' , Medicina (Lithuania) , vol. 48 , no. 6 , pp. 317-323 . https://doi.org/10.3390/medicina48060047 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4875 | - |
dc.description.abstract | Background and Objective: Gastric cancer is a frequent cause of cancer mortality. The prognosis of established tumor is unfavorable due to the propensity to spread and limited treatment efficiency. Therefore, prevention has a high significance. We tested a population screening approach in order to identify families with an increased gastric cancer load for further surveillance. Material and Methods: Population screening was performed by questionnaire reaching 76.6% of the population. Hereditary gastric cancer (HGC) syndrome was diagnosed if 3 mutually first-degree relatives with gastric cancer were reported in the kindred. Additional group (HGC2) of families with 2 first-degree relatives affected by gastric cancer was identified. Results: The HGC syndrome was diagnosed in 0.11%, but HGC2 syndrome, in 0.4% probands. The gastric cancer frequency among blood relatives was 25.2% (95% CI, 20.6%-30.4%) in HGC, but 16.0% (95% CI, 13.8%-18.5%) in HGC2 families. The mean age at diagnosis of cancer was 56.9 years (95% CI, 53.4-60.3) in HGC and 62.5 years (95% CI, 60.1-64.8) in HGC2. The mean survival was 2.6 years (95% CI, 1.2-4.0). Conclusions: Population screening identifies reasonable number of families with a high frequency of gastric cancer. The frequency of gastric cancer and an unfavorable course characterized by low survival justify surveillance in families with 2 or 3 first-degree relatives affected by gastric cancer. Population screening provides the age characteristics of the respective tumors in order to adjust the surveillance schedule. | en |
dc.format.extent | 7 | - |
dc.format.extent | 243547 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Familial gastric cancer | - |
dc.subject | Hereditary cancer | - |
dc.subject | Hereditary gastric cancer | - |
dc.subject | Population screening | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | The first evidence of hereditary and familial gastric cancer in Latvia : Implications for prevention | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina48060047 | - |
dc.contributor.institution | Department of Surgery | - |
dc.contributor.institution | Department of Pathology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84866630500&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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The_first_evidence_of_hereditary_and_familial_gastric_cancer.pdf | 237.84 kB | Adobe PDF | View/Open |
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