Please use this identifier to cite or link to this item:
10.3390/medicina48100074
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ozolins, Arturs | - |
dc.contributor.author | Narbuts, Zenons | - |
dc.contributor.author | Strumfa, Ilze | - |
dc.contributor.author | Volanska, Guna | - |
dc.contributor.author | Stepanovs, Kaspars | - |
dc.contributor.author | Gardovskis, Janis | - |
dc.date.accessioned | 2021-06-09T07:05:01Z | - |
dc.date.available | 2021-06-09T07:05:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Ozolins , A , Narbuts , Z , Strumfa , I , Volanska , G , Stepanovs , K & Gardovskis , J 2012 , ' Immunohistochemical expression of HBME-1, E-cadherin, and CD56 in the differential diagnosis of thyroid nodules ' , Medicina (Lithuania) , vol. 48 , no. 10 , pp. 507-514 . https://doi.org/10.3390/medicina48100074 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4808 | - |
dc.description | Copyright: Copyright 2020 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Background and Objective. Distinction between benign and malignant thyroid tumors is essential for proper clinical management. The aim of this study was to evaluate the diagnostic potential of a set of 3 molecular markers in the differential diagnosis of thyroid tumors. Material and Methods. Immunohistochemistry for HBME-1, E-cadherin (E-CAD), and CD56 was carried out in 36 follicular adenomas, 77 colloid goiters, 36 papillary thyroid carcinomas, and 14 follicular carcinomas. Sixty-eight thyroid fine needle aspiration(FNA) cases confirmed by subsequent surgical resection specimens were selected. Immunocytochemistry for HBME-1, E-CAD, and CD56 was performed in these cases, including 25 papillary thyroid carcinomas, 1 follicular carcinoma, 22 follicular adenomas, and 20 colloid goiters. Results. PTC was characterized by a decreased expression of E-CAD and CD56 contrary to the surrounding benign thyroid tissues. There was no HBME-1 expression in benignthyroid tissues, but it was high in papillary thyroid carcinomas and weak in follicular adenomas. The expression of E-CAD and CD56 was significantly higher in follicular adenomas than in the surrounding thyroid tissues. Analyzing the FNA material, HBME-1 expression was documented in 96% of papillary thyroid carcinomas, but there was no expression in the benign lesions. E-CAD and CD56 expression was significantly weakened in papillary thyroid carcinomas, but enhanced in follicular adenomas. Conclusions. HBME-1 was found only in malignant lesions and can be considered the most sensitive, specific single marker in papillary thyroid carcinomas. CD56 and E-CAD can assist in the decision-making on thebenign and malignant nature of the nodule. Immunocytochemistry is of value as an ancillary test to enhance the diagnostic accuracy of thyroid FNA samples. | en |
dc.format.extent | 8 | - |
dc.format.extent | 1355416 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | CD56 | - |
dc.subject | E-cadherin | - |
dc.subject | HBME-1 | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Thyroid nodules | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.title | Immunohistochemical expression of HBME-1, E-cadherin, and CD56 in the differential diagnosis of thyroid nodules | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina48100074 | - |
dc.contributor.institution | Department of Surgery | - |
dc.contributor.institution | Department of Pathology | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84875543577&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Immunohistochemical_expression_of_HBME_1.pdf | 1.32 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.