Please use this identifier to cite or link to this item:
10.21873/invivo.11043
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Naciute, Milda | - |
dc.contributor.author | Maciunaite, Gabriele | - |
dc.contributor.author | Mieliauskaite, Diana | - |
dc.contributor.author | Rugiene, Rita | - |
dc.contributor.author | Zinkeviciene, Aukse | - |
dc.contributor.author | Mauricas, Mykolas | - |
dc.contributor.author | Murovska, Modra | - |
dc.contributor.author | Girkontaite, Irute | - |
dc.date.accessioned | 2021-06-03T13:20:01Z | - |
dc.date.available | 2021-06-03T13:20:01Z | - |
dc.date.issued | 2017-03-01 | - |
dc.identifier.citation | Naciute , M , Maciunaite , G , Mieliauskaite , D , Rugiene , R , Zinkeviciene , A , Mauricas , M , Murovska , M & Girkontaite , I 2017 , ' Increased Numbers of CD4 + CD25 + and CD8 + CD25 + T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection ' , In Vivo , vol. 31 , no. 2 , pp. 181-185 . https://doi.org/10.21873/invivo.11043 | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4690 | - |
dc.description.abstract | Aim: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19+) and-negative (B19-) patients with rheumatoid arthritis (RA) and healthy persons. Patients and Methods: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19+. Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4+CD45RA+, CD4+CD45RA-, CD8+CD45RA+, CD8+CD45RA- subsets were analyzed by flow cytometry. Results: The percentage of CD25low and CD25hi cells was increased on CD4+CD45RA+, CD4+CD45RA-T-cells and the percentage of CD25+ cells was increased on CD8+CD45RA+, CD8+CD45RA-T-cells of B19+ patients with RA in comparison with B19- patients and controls. Conclusion: Raised levels of CD4 and CD8 regulatory T-cells in B19+ RA patients could cause downregulation of antiviral clearance mechanisms and lead to activation of persistent human parvovirus B19 infection in patients with RA. | en |
dc.format.extent | 5 | - |
dc.format.extent | 2391876 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | In Vivo | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | CD4CD25 | - |
dc.subject | CD8CD25 | - |
dc.subject | Parvovirus B19 | - |
dc.subject | Rheumatoid arthritis | - |
dc.subject | Treg | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Biochemistry,Genetics and Molecular Biology | - |
dc.subject | Pharmacology | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Increased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.21873/invivo.11043 | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85016078479&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Increased_Numbers_of_CD4.pdf | 2.34 MB | Adobe PDF | View/Open |
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