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Title: Increased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection
Authors: Naciute, Milda
Maciunaite, Gabriele
Mieliauskaite, Diana
Rugiene, Rita
Zinkeviciene, Aukse
Mauricas, Mykolas
Murovska, Modra
Girkontaite, Irute
Institute of Microbiology and Virology
Keywords: CD4CD25;CD8CD25;Parvovirus B19;Rheumatoid arthritis;Treg;1.6 Biological sciences;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Biochemistry, Genetics and Molecular Biology(all);Pharmacology
Issue Date: 1-Mar-2017
Citation: Naciute , M , Maciunaite , G , Mieliauskaite , D , Rugiene , R , Zinkeviciene , A , Mauricas , M , Murovska , M & Girkontaite , I 2017 , ' Increased Numbers of CD4 + CD25 + and CD8 + CD25 + T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection ' , In Vivo , vol. 31 , no. 2 , pp. 181-185 .
Abstract: Aim: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19+) and-negative (B19-) patients with rheumatoid arthritis (RA) and healthy persons. Patients and Methods: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19+. Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4+CD45RA+, CD4+CD45RA-, CD8+CD45RA+, CD8+CD45RA- subsets were analyzed by flow cytometry. Results: The percentage of CD25low and CD25hi cells was increased on CD4+CD45RA+, CD4+CD45RA-T-cells and the percentage of CD25+ cells was increased on CD8+CD45RA+, CD8+CD45RA-T-cells of B19+ patients with RA in comparison with B19- patients and controls. Conclusion: Raised levels of CD4 and CD8 regulatory T-cells in B19+ RA patients could cause downregulation of antiviral clearance mechanisms and lead to activation of persistent human parvovirus B19 infection in patients with RA.
ISSN: 0258-851X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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