Please use this identifier to cite or link to this item:
10.21873/invivo.11043
| Title: | Increased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection |
| Authors: | Naciute, Milda Maciunaite, Gabriele Mieliauskaite, Diana Rugiene, Rita Zinkeviciene, Aukse Mauricas, Mykolas Murovska, Modra Girkontaite, Irute Institute of Microbiology and Virology |
| Keywords: | CD4CD25;CD8CD25;Parvovirus B19;Rheumatoid arthritis;Treg;1.6 Biological sciences;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Biochemistry,Genetics and Molecular Biology;Pharmacology;SDG 3 - Good Health and Well-being |
| Issue Date: | 1-Mar-2017 |
| Citation: | Naciute , M , Maciunaite , G , Mieliauskaite , D , Rugiene , R , Zinkeviciene , A , Mauricas , M , Murovska , M & Girkontaite , I 2017 , ' Increased Numbers of CD4 + CD25 + and CD8 + CD25 + T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection ' , In Vivo , vol. 31 , no. 2 , pp. 181-185 . https://doi.org/10.21873/invivo.11043 |
| Abstract: | Aim: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19+) and-negative (B19-) patients with rheumatoid arthritis (RA) and healthy persons. Patients and Methods: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19+. Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4+CD45RA+, CD4+CD45RA-, CD8+CD45RA+, CD8+CD45RA- subsets were analyzed by flow cytometry. Results: The percentage of CD25low and CD25hi cells was increased on CD4+CD45RA+, CD4+CD45RA-T-cells and the percentage of CD25+ cells was increased on CD8+CD45RA+, CD8+CD45RA-T-cells of B19+ patients with RA in comparison with B19- patients and controls. Conclusion: Raised levels of CD4 and CD8 regulatory T-cells in B19+ RA patients could cause downregulation of antiviral clearance mechanisms and lead to activation of persistent human parvovirus B19 infection in patients with RA. |
| DOI: | 10.21873/invivo.11043 |
| ISSN: | 0258-851X |
| Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| Increased_Numbers_of_CD4.pdf | 2.34 MB | Adobe PDF | View/Open |
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