Increased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection

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dc.contributor.authorNaciute, Milda
dc.contributor.authorMaciunaite, Gabriele
dc.contributor.authorMieliauskaite, Diana
dc.contributor.authorRugiene, Rita
dc.contributor.authorZinkeviciene, Aukse
dc.contributor.authorMauricas, Mykolas
dc.contributor.authorMurovska, Modra
dc.contributor.authorGirkontaite, Irute
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2021-06-03T13:20:01Z
dc.date.available2021-06-03T13:20:01Z
dc.date.issued2017-03-01
dc.description.abstractAim: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19+) and-negative (B19-) patients with rheumatoid arthritis (RA) and healthy persons. Patients and Methods: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19+. Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4+CD45RA+, CD4+CD45RA-, CD8+CD45RA+, CD8+CD45RA- subsets were analyzed by flow cytometry. Results: The percentage of CD25low and CD25hi cells was increased on CD4+CD45RA+, CD4+CD45RA-T-cells and the percentage of CD25+ cells was increased on CD8+CD45RA+, CD8+CD45RA-T-cells of B19+ patients with RA in comparison with B19- patients and controls. Conclusion: Raised levels of CD4 and CD8 regulatory T-cells in B19+ RA patients could cause downregulation of antiviral clearance mechanisms and lead to activation of persistent human parvovirus B19 infection in patients with RA.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent2391876
dc.identifier.citationNaciute, M, Maciunaite, G, Mieliauskaite, D, Rugiene, R, Zinkeviciene, A, Mauricas, M, Murovska, M & Girkontaite, I 2017, 'Increased Numbers of CD4 + CD25 + and CD8 + CD25 + T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection', In Vivo, vol. 31, no. 2, pp. 181-185. https://doi.org/10.21873/invivo.11043
dc.identifier.doi10.21873/invivo.11043
dc.identifier.issn0258-851X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4690
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85016078479&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofIn Vivo
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCD4CD25
dc.subjectCD8CD25
dc.subjectParvovirus B19
dc.subjectRheumatoid arthritis
dc.subjectTreg
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectPharmacology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIncreased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infectionen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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