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Title: Human papillomavirus type 18 infection in a female renal allograft recipient : a case report
Authors: Cistjakovs, Maksims
Sultanova, Alina
Jermakova, Olga
Chapenko, Svetlana
Lesina-Korne, Baiba
Rozental, Rafail
Razeberga, Dace
Murovska, Modra
Ziedina, Ieva
Institute of Microbiology and Virology
Scientific Laboratory of Transplantology
Keywords: Case report;HPV-18;Immunosuppressive therapy;Renal allograft transplantation;1.6 Biological sciences;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Medicine(all)
Issue Date: 9-Nov-2016
Citation: Cistjakovs , M , Sultanova , A , Jermakova , O , Chapenko , S , Lesina-Korne , B , Rozental , R , Razeberga , D , Murovska , M & Ziedina , I 2016 , ' Human papillomavirus type 18 infection in a female renal allograft recipient : a case report ' , Journal of Medical Case Reports , vol. 10 , no. 1 , 318 .
Abstract: Background: Human papillomavirus type 18 is the second most common cause of cervical cancer and is found in 7 to 20 % of cases of cervical cancer. The oncogenic potential of high-risk human papillomavirus is associated with expression of early proteins E6 and E7. Due to long-term immunosuppressive therapy, renal transplant recipients have a higher risk of developing persistent human papillomavirus infection. Case presentation: A 29-year-old white woman from Latvia with chronic focal segmental glomerulosclerosis received renal allograft transplantation and was prescribed immunosuppressive therapy with cyclosporine, prednisolone, and mycophenolate mofetil. Two weeks after renal transplantation, her cervical swab was positive for human papillomavirus consensus sequences. After 6 months, quantitative polymerase chain reaction showed a high viral load of 3,630,789 copies/105 cells of high-risk human papillomavirus type 18 and expression of E6 and E7 oncogenes in her cervical swab and urine sample. One year after renal transplantation, the viral load in her cervical swab increased significantly to 7,413,102 copies/105 cells. Messenger ribonucleic acid of human papillomavirus type 18 E6 and E7 oncogenes were also detected. Shortly after this, she had an unsuccessful pregnancy which resulted in a spontaneous abortion at 6/7 weeks. Two months after the abortion her viral load sharply decreased to 39 copies/105 cells. Oncogenes E6 and E7 messenger ribonucleic acid expression was not observed in this period. Conclusions: This case report represents data which show that immunosuppressive therapy may increase the risk of developing persistent high-risk human papillomavirus infection with expression of E6 and E7 oncogenes in renal transplant recipients. However, even during this therapy the immune status of a recipient can improve and contribute to human papillomavirus viral load reduction. Spontaneous abortion can be considered a possible contributory factor in human papillomavirus clearance.
Description: Publisher Copyright: © 2016 The Author(s).
ISSN: 1752-1947
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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