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10.1016/j.medici.2014.05.001
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DC Field | Value | Language |
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dc.contributor.author | Leja, Marcis | - |
dc.contributor.author | Lapina, Sanita | - |
dc.contributor.author | Polaka, Inese | - |
dc.contributor.author | Rudzite, Dace | - |
dc.contributor.author | Vilkoite, Ilona | - |
dc.contributor.author | Daugule, Ilva | - |
dc.contributor.author | Belkovets, Anna | - |
dc.contributor.author | Pimanov, Sergey | - |
dc.contributor.author | Makarenko, Jelena | - |
dc.contributor.author | Tolmanis, Ivars | - |
dc.contributor.author | Lejnieks, Aivars | - |
dc.contributor.author | Boka, Viesturs | - |
dc.contributor.author | Rumba-Rozenfelde, Ingrida | - |
dc.contributor.author | Vikmanis, Uldis | - |
dc.date.accessioned | 2021-05-31T09:55:01Z | - |
dc.date.available | 2021-05-31T09:55:01Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Leja , M , Lapina , S , Polaka , I , Rudzite , D , Vilkoite , I , Daugule , I , Belkovets , A , Pimanov , S , Makarenko , J , Tolmanis , I , Lejnieks , A , Boka , V , Rumba-Rozenfelde , I & Vikmanis , U 2014 , ' Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy ' , Medicina (Lithuania) , vol. 50 , no. 1 , pp. 8-13 . https://doi.org/10.1016/j.medici.2014.05.001 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4581 | - |
dc.description | Funding Information: This study was supported in part from the European Fund for Regional Development project No. 2010/0302/2DP/2.1.1.1.0/10/APIA/VIAA/158 entitled “Development of a Genetic/Serological Biomarker Diagnostic Method for Early Identification of Autoimmune Gastrointestinal Lesions With Increased Malignancy Risk in Patients With Autoimmune Disease.” Publisher Copyright: © 2014 Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. Copyright: Copyright 2017 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Background and objective: Pepsinogen levels in plasma are increased by inflammation in the gastric mucosa, including inflammation resulting from Helicobacter pylori infection. A decrease in pepsinogen II level has been suggested as a reliable marker to confirm the successful eradication of infection. The aim of our study was to evaluate the potential role of pepsinogens I and II, gastrin-17 and H. pylori antibodies in confirming successful eradication. Material and methods: Altogether 42 patients (25 women, 17 men), mean age 45 years (range 23-74), were enrolled. Pepsinogens I and II, gastrin-17 and H. pylori IgG antibodies were measured in plasma samples using an ELISA test (Biohit, Oyj., Finland) before the eradication and 4 weeks after completing the treatment. The success of eradication was determined by a urea breath test. Results: Eradication was successful in 31 patients (74%) and unsuccessful in 11 patients (26%). Pepsinogen II decreased significantly in both the successful (P = 0.029) and unsuccessful (P = 0.042) eradication groups. Pepsinogen I decreased significantly in the successful (P = 0.025) but not the unsuccessful (P = 0.29) eradication group. The pepsinogen I/II ratio increased in the successful eradication group (P = 0.0018) but not in the group in which treatment failed (P = 0.12). There were no differences in gastrin-17 or H. pylori antibody values. Conclusions: A decrease in pepsinogen II levels cannot be used as a reliable marker for the successful eradication of H. pylori 4 weeks after the completion of treatment. The increase in pepsinogen I/II ratio reflects differences in pepsinogen production following the eradication irrespective of improvement in atrophy. | en |
dc.format.extent | 6 | - |
dc.format.extent | 706109 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina (Lithuania) | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Efficacy | - |
dc.subject | Eradication | - |
dc.subject | Gastrin-17 | - |
dc.subject | Helicobacter pylori | - |
dc.subject | Pepsinogen | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.title | Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1016/j.medici.2014.05.001 | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84906965400&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Pepsinogen_testing_for_evaluation_of_the_success_of_Helicobacter.pdf | 689.56 kB | Adobe PDF | View/Open |
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