Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0008
Title: | Diagnostic value of tumour markers CA-125 and CEA in the diagnostics of malignant pleural fluids |
Authors: | Žentiņa, Dace Stukěna, Inga Grînberga, Sarma Krams, Alvils Lejnieks, Aivars Department of Internal Diseases |
Keywords: | CA-125;CEA;Malignant effusion;Pleural fluid;Tumour markers;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General;SDG 3 - Good Health and Well-being |
Issue Date: | Apr-2016 |
Citation: | Žentiņa , D , Stukěna , I , Grînberga , S , Krams , A & Lejnieks , A 2016 , ' Diagnostic value of tumour markers CA-125 and CEA in the diagnostics of malignant pleural fluids ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 2 , pp. 41-46 . https://doi.org/10.1515/prolas-2016-0008 |
Abstract: | The significance of carbohydrate (cancer) antigen 125 (Ca-125) and carcinoembryonic antigen (CEA) tumour markers levels in differential diagnostics of malignant and benign pleural effusion was studied. Within this prospective study, 121 patients with fluids of various aetiology in the pleural cavity were analysed. Malignant pleural effusion was detected in 55 patients, parapneumonic effusion in 28 patients, transudative effusion of cardiac origin in 31 patients, pancreatitis in one patient and tuberculous pleurisy in five patients. The highest accuracy in diagnosis of malignancy was observed for Ca-125 and CEA levels in the pleural fluid: 75.2% at cut-off value ≥1452 U/mL and 76.9% at cut-off value ≥6.58 ng/mL, respectively. We conclude that the level of tumour markers in pleural fluid has additional diagnostic significance in the differential diagnosis of malignant and benign pleural effusions. |
Description: | Copyright: Copyright 2016 Elsevier B.V., All rights reserved. |
DOI: | 10.1515/prolas-2016-0008 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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DIAGNOSTIC_VALUE_OF_TUMOUR_MARKERS.pdf | 332.23 kB | Adobe PDF | View/Open |
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