Please use this identifier to cite or link to this item:
10.32607/20758251-2013-5-1-85-89
| Title: | Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells |
| Authors: | Shevchuk, Z. Yurchenko, M. Y. Darekar, S. D. Holodnuka-Kholodnyuk, I. Kashuba, V. I. Kashuba, E. V. Institute of Microbiology and Virology |
| Keywords: | Cancer cell line;Cell cycle;Mitochondrial ribosomal protein S18-2 (MRPS18-2);Multinucleated cells;RB binding protein;1.6 Biological sciences;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Biotechnology;Biochemistry;Molecular Medicine;Molecular Biology;SDG 3 - Good Health and Well-being |
| Issue Date: | 2013 |
| Citation: | Shevchuk , Z , Yurchenko , M Y , Darekar , S D , Holodnuka-Kholodnyuk , I , Kashuba , V I & Kashuba , E V 2013 , ' Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells ' , Acta Naturae , vol. 5 , no. 16 , pp. 85-89 . https://doi.org/10.32607/20758251-2013-5-1-85-89 |
| Abstract: | Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-independent growth pattern. Moreover, pathways characteristic for rapidly proliferating cells were upregulated then. It is possible that the S18-2 overexpression induced disturbance in cell cycle regulation. We found that overexpression of S18-2 protein in human cancer cell lines led to an appearance of multinucleated cells in the selected clones. |
| Description: | Copyright: Copyright 2020 Elsevier B.V., All rights reserved. |
| DOI: | 10.32607/20758251-2013-5-1-85-89 |
| ISSN: | 2075-8251 |
| Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| Overexpression_of_MRPS18_2_in_Cancer_Cell.pdf | 10.19 MB | Adobe PDF | View/Open |
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