Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0033
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DC Field | Value | Language |
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dc.contributor.author | Januškevica, Inga | - |
dc.contributor.author | Rozentale, Baiba | - |
dc.contributor.author | Hagina, Elvīra | - |
dc.contributor.author | Eglīte, Jeļena | - |
dc.contributor.author | Kolupajeva, Tatjana | - |
dc.contributor.author | Storozenko, Jeļena | - |
dc.contributor.author | Guseva, Ludmila | - |
dc.contributor.author | Lejnieks, Aivars | - |
dc.date.accessioned | 2021-05-17T12:50:01Z | - |
dc.date.available | 2021-05-17T12:50:01Z | - |
dc.date.issued | 2016-08-01 | - |
dc.identifier.citation | Januškevica , I , Rozentale , B , Hagina , E , Eglīte , J , Kolupajeva , T , Storozenko , J , Guseva , L & Lejnieks , A 2016 , ' Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in HIV-1 and HIV-1 + Mycobacterium Tuberculosis (Tb) Infected Patients ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 211-214 . https://doi.org/10.1515/prolas-2016-0033 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4334 | - |
dc.description | Publisher Copyright: © 2016 by Inga Januškevica. Copyright: Copyright 2016 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | The aim of this research was to investigate the role of IFN-γ in interaction between IL-10, IL-18, IL-1b, CD4 cell counts and HIV-1 RNA viral load in the development of HIV-1 in patients co-infected with Mycobacterium tuberculosis (TB). The study was conducted by Rīga East Clinical University Hospital with data from the HIV-1 register, in collaboration with the RSU Joint Laboratory of Clinical Immunology and Immunogenetics. 200 HIV-1 infected patients and 184 HIV-1 with TB co-infection patients divided in four groups were included in the study. IFN-γ, IL-10, IL-18, IL-1b levels were measured in serum with commercially enzyme-linked immunosorbent assay (ELISA Vector-Best Corporation, Novosibirsk, Russia). CD4 cell counts were measured by flow Partec IVD cytometry (USA). HIV-1 RNA quantification was performed using the COBAS AmpliPrep/COBAS Taqman HIV-1 Test (Germany). All groups were compared with each another. IFN-γ production was significantly lower, and IL-10 and CD4 cell counts were significantly higher, in HIV-1 patients without TB compared with the other groups. The group with HIV-1 and TB had significantly elevated IL-18 production. HIV patients with primary TB had significantly elevated IFN-γ production and HIV-1 RNA viral load and significantly lower IL-10 production. | en |
dc.format.extent | 4 | - |
dc.format.extent | 445040 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | cytokines | - |
dc.subject | HIV-1 | - |
dc.subject | IFN-γ | - |
dc.subject | Mycobacterium tuberculosis | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in HIV-1 and HIV-1 + Mycobacterium Tuberculosis (Tb) Infected Patients | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1515/prolas-2016-0033 | - |
dc.contributor.institution | Department of Internal Diseases | - |
dc.contributor.institution | Joint Laboratory of Clinical Immunology and Immunogenetics | - |
dc.contributor.institution | Department of Infectology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84983438885&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
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Role_of_Interferon_Gamma_Ifn_in_Immune_Response.pdf | 434.61 kB | Adobe PDF | View/Open |
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