Please use this identifier to cite or link to this item:
10.3390/diagnostics11050860
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DC Field | Value | Language |
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dc.contributor.author | Kakar, Mohit | - |
dc.contributor.author | Berezovska, Marisa Maija | - |
dc.contributor.author | Broks, Renars | - |
dc.contributor.author | Asare, Lasma | - |
dc.contributor.author | Delorme, Mathilde | - |
dc.contributor.author | Crouzen, Emile | - |
dc.contributor.author | Zviedre, Astra | - |
dc.contributor.author | Reinis, Aigars | - |
dc.contributor.author | Engelis, Arnis | - |
dc.contributor.author | Kroica, Juta | - |
dc.contributor.author | Saxena, Amulya | - |
dc.contributor.author | Petersons, Aigars | - |
dc.date.accessioned | 2021-05-13T10:55:01Z | - |
dc.date.available | 2021-05-13T10:55:01Z | - |
dc.date.issued | 2021-05-11 | - |
dc.identifier.citation | Kakar , M , Berezovska , M M , Broks , R , Asare , L , Delorme , M , Crouzen , E , Zviedre , A , Reinis , A , Engelis , A , Kroica , J , Saxena , A & Petersons , A 2021 , ' Serum and Urine Biomarker Leucine-Rich Alpha-2 Glycoprotein 1 Differentiates Pediatric Acute Complicated and Uncomplicated Appendicitis ' , Diagnostics , vol. 11 , no. 5 , 860 . https://doi.org/10.3390/diagnostics11050860 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.other | unpaywall: 10.3390/diagnostics11050860 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4234 | - |
dc.description | Funding Information: This research received grant support from the Latvian Council of Science and Riga?s Stradins University. Grant support was used for the laboratory materials for biological specimen collection. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.abstract | Purpose: This prospective, single-center cohort study analyzes the potential of inflammatory protein mediator leucine-rich alpha-2 glycoprotein 1 (LRG1) for the early and accurate diagnosis of acute appendicitis (AA), and differentiation of acute complicated (AcA) from uncomplicated appendicitis (AuA). Methods: Participants were divided into the AcA, AuA, and control groups, and their serum (s-LRG1) and urine LRG1 (u-LRG1) levels were assayed preoperatively on the second and fifth postoperative days. Results: 153 patients participated, 97 had AA. Preoperative u-LRG1 with a cut-off value of 0.18 µg/mL generated an area under the receiver operated characteristic (AUC) curve of 0.70 (95% CI 0.62–0.79) for AA versus control (p < 0.001), while the results for AcA versus AuA were not significant (AUC 0.60, 95% CI 0.49–0.71, p = 0.089). The s-LRG1 levels of AA versus the control with a cut-off value of 51.69 µg/mL generated an AUC of 0.94 (95% CI 0.91–0.99, p < 0.001). The cut-off value of s-LRG1 was 84.06 µg/mL for diagnosis of AcA from AuA, and therefore, significant (AUC 0.69, 95% CI 0.59–0.80, p = 0.001). Conclusions: LRG1 exhibited excellent diagnostic performance as an inexpensive, non-invasive, rapid, and accurate biomarker able to reflect the pathogenesis of AA. LRG1 has the potential to replace advanced imaging to diagnose clinically ambiguous AA cases. | en |
dc.format.extent | 12 | - |
dc.format.extent | 959138 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Diagnostics | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | pediatric appendicitis | - |
dc.subject | biomarkers | - |
dc.subject | serum LRG1 | - |
dc.subject | urine LRG1 | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.title | Serum and Urine Biomarker Leucine-Rich Alpha-2 Glycoprotein 1 Differentiates Pediatric Acute Complicated and Uncomplicated Appendicitis | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/diagnostics11050860 | - |
dc.contributor.institution | Department of Paediatric Surgery | - |
dc.contributor.institution | Department of Biology and Microbiology | - |
dc.contributor.institution | Statistics Unit | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85106535391&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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