Please use this identifier to cite or link to this item:
10.1111/bcpt.12775
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DC Field | Value | Language |
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dc.contributor.author | Kuka, Janis | - |
dc.contributor.author | Makrecka-Kuka, Marina | - |
dc.contributor.author | Cirule, Helena | - |
dc.contributor.author | Grinberga, Solveiga | - |
dc.contributor.author | Sevostjanovs, Eduards | - |
dc.contributor.author | Dambrova, Maija | - |
dc.contributor.author | Liepinsh, Edgars | - |
dc.date.accessioned | 2021-05-11T13:10:01Z | - |
dc.date.available | 2021-05-11T13:10:01Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Kuka , J , Makrecka-Kuka , M , Cirule , H , Grinberga , S , Sevostjanovs , E , Dambrova , M & Liepinsh , E 2017 , ' Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB ' , Basic and Clinical Pharmacology and Toxicology , vol. 121 , no. 2 , pp. 106-112 . https://doi.org/10.1111/bcpt.12775 | - |
dc.identifier.issn | 1742-7835 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4161 | - |
dc.description | Publisher Copyright: © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society) | - |
dc.description.abstract | Ischaemia in the heart is accompanied by the accumulation of long-chain acylcarnitines (LCACs) which is one of the multiple factors that contribute to the ischaemia–reperfusion damage development. Long-term pre-treatment that decreases carnitine and LCAC contents also reduces ischaemia–reperfusion (IR) damage; however, the duration of the post-treatment effects is not known. The aim of the study was to assess the post-treatment effects of the carnitine transport (OCTN2) inhibitor, methyl-GBB, on LCAC content and the duration of its cardioprotective effect. Male Wistar rats received methyl-GBB (5 mg/kg for 28 days), and the anti-infarction effects on Langendorff-perfused hearts and the acylcarnitine profile in cardiac tissues were measured up to 28 days following the end of the treatment. Methyl-GBB pre-treatment for 28 days decreased LCAC heart tissue content by 87%, and the infarct size was decreased by 57%. Fourteen days post-treatment, the LCAC content was still decreased by 69%, and the infarct size was decreased by 32% compared to Control. A significant Pearson correlation (r = 0.48, p = 0.026) was found between infarct size and LCAC tissue content in the methyl-GBB-treated rat hearts. The addition of 2 mM carnitine to isolated heart perfusate significantly diminished the methyl-GBB-induced decrease in LCACs and infarct size. In conclusion, the anti-infarction effect of methyl-GBB continues for at least 2 weeks post-treatment. No less than a 70% decrease in LCAC content is required to protect ischaemic heart tissues, and the decrease in LCAC levels defines the duration of the post-treatment cardioprotective effect of the OCTN2 inhibitor, methyl-GBB. | en |
dc.format.extent | 7 | - |
dc.format.extent | 172715 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Basic and Clinical Pharmacology and Toxicology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Toxicology | - |
dc.subject | Pharmacology | - |
dc.title | Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1111/bcpt.12775 | - |
dc.contributor.institution | Faculty of Pharmacy | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85018337707&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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Decrease_in_Long_Chain_Acylcarnitine.pdf | 168.67 kB | Adobe PDF | View/Open |
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