Please use this identifier to cite or link to this item:
10.2478/prolas-2018-0038
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DC Field | Value | Language |
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dc.contributor.author | Nazarovs, Jurijs | - |
dc.contributor.author | Kleina, Regna | - |
dc.contributor.author | Lejniece, Sandra | - |
dc.date.accessioned | 2021-05-11T09:45:01Z | - |
dc.date.available | 2021-05-11T09:45:01Z | - |
dc.date.issued | 2018-10-01 | - |
dc.identifier.citation | Nazarovs , J , Kleina , R & Lejniece , S 2018 , ' The Importance of Cyclin D1, P53, Cd56 Antigen Expression in Plasma Cells and its Correlation with Serological and Clinical Parameters in Patients with Multiple Myeloma ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 72 , no. 5 , pp. 259-267 . https://doi.org/10.2478/prolas-2018-0038 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/4155 | - |
dc.description | Publisher Copyright: © 2018 Jurijs Nazarovs et al. | - |
dc.description.abstract | CD56, p53, and Cyclin D1 detection in plasma cells (PC) can help to predict prognosis of multiple myeloma (MM). Clinical and biochemical prognostic parameters were analysed in a group of 122 patients with primary diagnosed MM in the period 2011-2015. Bone marrow biopsies were analysed with Cyclin D1, p53, CD56 antibodies. Statistical analysis was performed using Microsoft Excel 2010 and Graph Pad Prism 5. Lack of CD56 expression and p53-positivity were significantly correlated with a low glomerular filtration rate (GFR), low platelet count and haemoglobin level, as well as with high serum creatinine levels. Patients with Cyclin D1 expression in PC had a significantly higher serum calcium level and more common osteolytic lesion in bones. CD56-negative as well as p53, Cyclin D1-positive groups had advanced Salmon-Durie MM stages by and significantly higher ß2-microglobulin. Expression of p53, Cyclin D1 and lack of CD56 antigen in PC are negative predictive factors in cases of MM, as these patients were diagnosed as having late Salmon-Durie stage and higher ß2-microglobulin level. Expression of p53 and lack of CD56 antigen in PC is associated with an increased creatinine level in blood and decreased GFR; therefore, these are criteria for chronic renal failure progression and poorer prognosis of MM. | en |
dc.format.extent | 9 | - |
dc.format.extent | 1810067 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | CD56 | - |
dc.subject | Cyclin D1 | - |
dc.subject | multiple myeloma | - |
dc.subject | p53 | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.title | The Importance of Cyclin D1, P53, Cd56 Antigen Expression in Plasma Cells and its Correlation with Serological and Clinical Parameters in Patients with Multiple Myeloma | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2478/prolas-2018-0038 | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.contributor.institution | Department of Pathology | - |
dc.contributor.institution | Department of Internal Diseases | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85055493364&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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The_Importance_of_Cyclin_D1_P53_CD56_Antigen_Expre.pdf | 1.77 MB | Adobe PDF | View/Open![]() |
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