Please use this identifier to cite or link to this item:
10.3390/medicina55040092
Title: | Prevalence, discontinuation rate, and risk factors for severe local site reactions with topical field treatment options for actinic keratosis of the face and scalp |
Authors: | Balcere, Alise Kupfere, Māra Rone Čēma, Ingrīda Krūmiņa, Angelika Department of Dermatology and Venereology Department of Oral Medicine Department of Infectology |
Keywords: | Actinic keratosis;Review;Risk factors;Severe local site reactions;Topical therapy;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine;SDG 3 - Good Health and Well-being |
Issue Date: | Apr-2019 |
Citation: | Balcere , A , Kupfere , M R , Čēma , I & Krūmiņa , A 2019 , ' Prevalence, discontinuation rate, and risk factors for severe local site reactions with topical field treatment options for actinic keratosis of the face and scalp ' , Medicina (Lithuania) , vol. 55 , no. 4 , 92 . https://doi.org/10.3390/medicina55040092 |
Abstract: | Actinic keratoses (AKs) are common lesions on chronically sun damaged skin, which are morphologically characterized by lower third to full thickness atypia of epidermal keratinocytes. These lesions carry a risk of progression towards invasive squamous cell carcinoma (SCC); therefore, treatment of visible lesions and the field in case of field cancerization is recommended. Treatment of AK includes the destruction of atypical keratinocytes that clinically presents with various degrees of erythema, scaling, crusting, erosion, and other visible and subjective symptoms. Such inflammatory reactions may have an impact on the patient’s social life and have shown to decrease compliance and adherence to therapy. Additionally, as various topical treatments have been proven to be effective in treating AK, tolerability of local site reactions (LSRs) might drive the decision for appropriate treatment in an individual scenario. Therefore, we aimed to review prevalence of severe LSRs among various topical treatments for AK. In addition, we summarized discontinuation rates due to LSRs and possible therapy-unrelated risk factors for the development of LSRs with increased severity. |
Description: | Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/medicina55040092 |
ISSN: | 1010-660X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Prevalence_Discontinuation_Rate_and_Risk_Factors.pdf | 474.62 kB | Adobe PDF | View/Open |
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