Please use this identifier to cite or link to this item: 10.2337/db11-1000
Title: Interbirth interval is associated with childhood type 1 diabetes risk
Authors: Cardwell, Chris R.
Svensson, Jannet
Waldhoer, Thomas
Ludvigsson, Johnny
Sadauskaite-Kuehne, Vaiva
Roberts, Christine L.
Parslow, Roger C.
Wadsworth, Emma J. K.
Brigis, Girts
Urbonaite, Brone
Schober, Edith
Devoti, Gabriele
Ionescu-Tirgoviste, Constantin
de Beaufort, Carine E.
Soltesz, Gyula
Patterson, Chris C.
Department of Public Health and Epidemiology
Keywords: 3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Internal Medicine;Endocrinology, Diabetes and Metabolism;SDG 3 - Good Health and Well-being
Issue Date: Mar-2012
Citation: Cardwell , C R , Svensson , J , Waldhoer , T , Ludvigsson , J , Sadauskaite-Kuehne , V , Roberts , C L , Parslow , R C , Wadsworth , E J K , Brigis , G , Urbonaite , B , Schober , E , Devoti , G , Ionescu-Tirgoviste , C , de Beaufort , C E , Soltesz , G & Patterson , C C 2012 , ' Interbirth interval is associated with childhood type 1 diabetes risk ' , Diabetes , vol. 61 , no. 3 , pp. 702-707 . https://doi.org/10.2337/db11-1000 , https://doi.org/10.2337/db11-1000
Abstract: Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals β3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals β3 years.
DOI: 10.2337/db11-1000
ISSN: 0012-1797
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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