Please use this identifier to cite or link to this item:
10.2337/dc12-0438
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DC Field | Value | Language |
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dc.contributor.author | Cardwell, Chris R. | - |
dc.contributor.author | Stene, Lars C. | - |
dc.contributor.author | Ludvigsson, Johnny | - |
dc.contributor.author | Rosenbauer, Joachim | - |
dc.contributor.author | Cinek, Ondrej | - |
dc.contributor.author | Svensson, Jannet | - |
dc.contributor.author | Perez-Bravo, Francisco | - |
dc.contributor.author | Memon, Anjum | - |
dc.contributor.author | Gimeno, Suely G. | - |
dc.contributor.author | Wadsworth, Emma J.K. | - |
dc.contributor.author | Strotmeyer, Elsa S. | - |
dc.contributor.author | Goldacre, Michael J. | - |
dc.contributor.author | Radon, Katja | - |
dc.contributor.author | Chuang, Lee Ming | - |
dc.contributor.author | Parslow, Roger C. | - |
dc.contributor.author | Chetwynd, Amanda | - |
dc.contributor.author | Karavanaki, Kyriaki | - |
dc.contributor.author | Brigis, Girts | - |
dc.contributor.author | Pozzilli, Paolo | - |
dc.contributor.author | Urbonaite, Brone | - |
dc.contributor.author | Schober, Edith | - |
dc.contributor.author | Devoti, Gabriele | - |
dc.contributor.author | Sipetic, Sandra | - |
dc.contributor.author | Joner, Geir | - |
dc.contributor.author | Ionescu-Tirgoviste, Constantin | - |
dc.contributor.author | De Beaufort, Carine E. | - |
dc.contributor.author | Harrild, Kirsten | - |
dc.contributor.author | Benson, Victoria | - |
dc.contributor.author | Savilahti, Erkki | - |
dc.contributor.author | Ponsonby, Anne Louise | - |
dc.contributor.author | Salem, Mona | - |
dc.contributor.author | Rabiei, Samira | - |
dc.contributor.author | Patterson, Chris C. | - |
dc.date.accessioned | 2021-04-28T20:15:01Z | - |
dc.date.available | 2021-04-28T20:15:01Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | Cardwell , C R , Stene , L C , Ludvigsson , J , Rosenbauer , J , Cinek , O , Svensson , J , Perez-Bravo , F , Memon , A , Gimeno , S G , Wadsworth , E J K , Strotmeyer , E S , Goldacre , M J , Radon , K , Chuang , L M , Parslow , R C , Chetwynd , A , Karavanaki , K , Brigis , G , Pozzilli , P , Urbonaite , B , Schober , E , Devoti , G , Sipetic , S , Joner , G , Ionescu-Tirgoviste , C , De Beaufort , C E , Harrild , K , Benson , V , Savilahti , E , Ponsonby , A L , Salem , M , Rabiei , S & Patterson , C C 2012 , ' Breast-feeding and childhood-onset type 1 diabetes : A pooled analysis of individual participant data from 43 observational studies ' , Diabetes Care , vol. 35 , no. 11 , pp. 2215-2225 . https://doi.org/10.2337/dc12-0438 | - |
dc.identifier.issn | 0149-5992 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3980 | - |
dc.description.abstract | OBJECTIVE - To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. RESEARCH DESIGN AND METHODS - Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. RESULTS - Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for >2 weeks (20 studies; OR = 0.75, 95% CI 0.64- 0.88), the association after exclusive breast-feeding for >3 months was weaker (30 studies;OR = 0.87, 95%CI 0.75 -1.00), and no association was observed after (nonexclusive) breast-feeding for >2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or >3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I 2 = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for >2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I 2 = 0%). Adjustments for potential confounders altered these estimates very little. CONCLUSIONS - The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies. | en |
dc.format.extent | 11 | - |
dc.format.extent | 358017 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Diabetes Care | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Internal Medicine | - |
dc.subject | Endocrinology, Diabetes and Metabolism | - |
dc.subject | Advanced and Specialised Nursing | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Breast-feeding and childhood-onset type 1 diabetes : A pooled analysis of individual participant data from 43 observational studies | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2337/dc12-0438 | - |
dc.contributor.institution | Department of Public Health and Epidemiology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84868121007&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Breast_Feeding_and_Childhood_Onset_Type_1_Diabetes.pdf | 349.63 kB | Adobe PDF | View/Open |
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