Please use this identifier to cite or link to this item:
10.4067/S0717-95022015000200037
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Smane, Liene | - |
dc.contributor.author | Pilmane, Mara | - |
dc.date.accessioned | 2021-04-28T11:50:01Z | - |
dc.date.available | 2021-04-28T11:50:01Z | - |
dc.date.issued | 2015-06-01 | - |
dc.identifier.citation | Smane , L & Pilmane , M 2015 , ' Expresión de IRF6, RYK y PAX9 en el tejido facial de niños con paladar fisurado ' , International Journal of Morphology , vol. 33 , no. 2 , pp. 647-652 . https://doi.org/10.4067/S0717-95022015000200037 | - |
dc.identifier.issn | 0717-9367 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3976 | - |
dc.description | Publisher Copyright: © 2015, Universidad de la Frontera. All rights reserved. | - |
dc.description.abstract | Cleft lip and palate (CLP) is a congenital anomaly characterized by the inappropriate fusion of the upper lip, alveolus, and secondary palate. This study investigated whether expression of interferon regulatory fac tor 6 (IRF6), receptor-like tyrosine kinase (RYK), and paired-box 9 (PAX9), which are essential for the normal development and morphogenesis of craniofacial structures, is dysregulated in children with CLP. Oral mucosa tissue samples were obtained from patients with complete bilateral (CB) CLP (n= 19) during corrective plastic surgery and unaffected control subjects (n= 7). IRF6, RYK, and PAX9 expression was assessed by immunohistochemistry, and data were analyzed with the Mann-Whitney test. In patients, IRF6 immunoreactivity in the connective tissue was moderate to high, but the overall number of IRF6-positive oral epithelial cells was lower than that in controls (z= -3.41; P= 0.01). RYK expression was observed only sporadically in the oral epithelium of 4 patients, in contrast to the control group (z= -3.75; P< 0.001). PAX9-positive epithelial cells were present in low to moderate numbers in patients with CBCLP, while an abundance of these cells was observed in the basal layer of the oral epithelium in controls (z= -3.60; P<0.001). IRF6 is the main connective tissue regulatory factor in CBCLP, and its low level of expression in the oral epithelium suggests a reduced potential for epitheliocyte differentiation, while low PAX9 and RYK expression may explain the decreased cell migration and cleft remodeling in CBCLP. | en |
dc.format.extent | 6 | - |
dc.format.extent | 160347 | - |
dc.language.iso | spa | - |
dc.relation.ispartof | International Journal of Morphology | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Cleft palate | - |
dc.subject | Interferon regulatory factor 6 | - |
dc.subject | Paired box gene 9 | - |
dc.subject | Receptor-like tyrosine kinase | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Anatomy | - |
dc.title | Expresión de IRF6, RYK y PAX9 en el tejido facial de niños con paladar fisurado | es |
dc.title.alternative | IRF6, RYK, and PAX9 expression in facial tissue of children with cleft palate | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.4067/S0717-95022015000200037 | - |
dc.contributor.institution | Institute of Anatomy and Anthropology | - |
dc.contributor.institution | Department of Morphology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84939497379&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
IRF6_RYK_and_PAX9_expression.pdf | 156.59 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.