Please use this identifier to cite or link to this item:
10.3390/medicina46030029
| Title: | Cell proliferation and apoptosis in wistar rat kidney after renal mass ablation and low-dose irradiation |
| Authors: | Aunapuu, Marina Arend, Andres Ots, Mai Pilmane, Mara Institute of Anatomy and Anthropology |
| Keywords: | Apoptosis;Cell proliferation;Low-dose radiation;Rat;Remnant kidney;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine |
| Issue Date: | 2010 |
| Citation: | Aunapuu , M , Arend , A , Ots , M & Pilmane , M 2010 , ' Cell proliferation and apoptosis in wistar rat kidney after renal mass ablation and low-dose irradiation ' , Medicina , vol. 46 , no. 3 , pp. 204-210 . https://doi.org/10.3390/medicina46030029 |
| Abstract: | Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated. Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9). Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation. Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury. |
| DOI: | 10.3390/medicina46030029 |
| ISSN: | 1010-660X |
| Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| Cell_proliferation_and_apoptosis.pdf | 252.95 kB | Adobe PDF | View/Open |
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