Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.dib.2019.104623
Title: Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry
Authors: Svalbe, Baiba
Grinberga, Solveiga
Stelfa, Gundega
Vavers, Edijs
Zvejniece, Baiba
Sevostjanovs, Eduards
Dambrova, Maija
Zvejniece, Liga
Rīga Stradiņš University
Keywords: Bioavailability;i.p. and s.c. administration route;Mice;MK-801;UPLC-MS/MS;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General
Issue Date: Dec-2019
Citation: Svalbe , B , Grinberga , S , Stelfa , G , Vavers , E , Zvejniece , B , Sevostjanovs , E , Dambrova , M & Zvejniece , L 2019 , ' Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry ' , Data in Brief , vol. 27 , 104623 . https://doi.org/10.1016/j.dib.2019.104623
Abstract: MK-801, a N-methyl-D-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled “Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration” [1].
Description: Funding Information: This research was supported by the European Regional Development Fund (ERDF) project No. 1.1.1.2/VIAA/1/16/244 “The role of sigma-1 receptor in sexual behavior”. Publisher Copyright: © 2019 The Author(s)
DOI: https://doi.org/10.1016/j.dib.2019.104623
ISSN: 2352-3409
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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