Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry

Simple item page
dc.contributor.authorSvalbe, Baiba
dc.contributor.authorGrinberga, Solveiga
dc.contributor.authorStelfa, Gundega
dc.contributor.authorVavers, Edijs
dc.contributor.authorZvejniece, Baiba
dc.contributor.authorSevostjanovs, Eduards
dc.contributor.authorDambrova, Maija
dc.contributor.authorZvejniece, Liga
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-04-28T07:50:02Z
dc.date.available2021-04-28T07:50:02Z
dc.date.issued2019-12
dc.descriptionFunding Information: This research was supported by the European Regional Development Fund (ERDF) project No. 1.1.1.2/VIAA/1/16/244 “The role of sigma-1 receptor in sexual behavior”. Publisher Copyright: © 2019 The Author(s)
dc.description.abstractMK-801, a N-methyl-D-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled “Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration” [1].en
dc.description.statusPeer reviewed
dc.format.extent456019
dc.identifier.citationSvalbe, B, Grinberga, S, Stelfa, G, Vavers, E, Zvejniece, B, Sevostjanovs, E, Dambrova, M & Zvejniece, L 2019, 'Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry', Data in Brief, vol. 27, 104623. https://doi.org/10.1016/j.dib.2019.104623
dc.identifier.doi10.1016/j.dib.2019.104623
dc.identifier.issn2352-3409
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3949
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068505948&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofData in Brief
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBioavailability
dc.subjecti.p. and s.c. administration route
dc.subjectMice
dc.subjectMK-801
dc.subjectUPLC-MS/MS
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleData on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Data_on_analysis_of_MK_801_bioavailability.pdf
Size:
445.33 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure