Please use this identifier to cite or link to this item:
10.2174/1874372201711010046
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Sidhom, Elga | - |
dc.contributor.author | Pilmane, Mara | - |
dc.date.accessioned | 2021-04-22T13:40:02Z | - |
dc.date.available | 2021-04-22T13:40:02Z | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.citation | Sidhom , E & Pilmane , M 2017 , ' Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip ' , Open Dermatology Journal , vol. 11 , pp. 46-52 . https://doi.org/10.2174/1874372201711010046 | - |
dc.identifier.issn | 1874-3722 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3907 | - |
dc.description | Publisher Copyright: © 2017 Sidhom and Pilmane. | - |
dc.description.abstract | Background: Orofacial clefts are one of the most common birth defects with multifactorial and only partly understood morphopathogenesis. Objective: The aim of this study was to evaluate the presence of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip. Methods: Lip mucosa tissue samples were obtained during surgical cleft correction from seven 2 to 6 months old children. Prepared tissue sections were stained by immunohistochemistry for TGF-β1, HGF, IGF-1 and IGF-1R. The intensity of staining was graded semiquantitatively. Results: We found numerous TGF-β1 and HGF-containing epithelial and connective tissue cells, moderate number of IGF-1 immunoreactive cells and even less pronounced presence of IGF-1R-positive cells. Conclusion: TGF-β1 and HGF are present in defective epithelia and soft tissue in cleft affected lip. Expressions of IGF-1 and IGF-1R show significant differences, and both factors play a role in the morphopathogenesis of clefts. | en |
dc.format.extent | 7 | - |
dc.format.extent | 407835 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Open Dermatology Journal | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Cleft | - |
dc.subject | HGF | - |
dc.subject | IGF-1 | - |
dc.subject | IGF-1R | - |
dc.subject | Lip mucosa | - |
dc.subject | Orofacial defects | - |
dc.subject | TGF-β1 | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Dermatology | - |
dc.title | Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2174/1874372201711010046 | - |
dc.contributor.institution | Institute of Anatomy and Anthropology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85032740544&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Detection_of_TGF_1.pdf | 398.28 kB | Adobe PDF | View/Open |
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