Please use this identifier to cite or link to this item:
10.2174/1874372201711010046
Title: | Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip |
Authors: | Sidhom, Elga Pilmane, Mara Institute of Anatomy and Anthropology |
Keywords: | Cleft;HGF;IGF-1;IGF-1R;Lip mucosa;Orofacial defects;TGF-β1;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Dermatology |
Issue Date: | 1-Sep-2017 |
Citation: | Sidhom , E & Pilmane , M 2017 , ' Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip ' , Open Dermatology Journal , vol. 11 , pp. 46-52 . https://doi.org/10.2174/1874372201711010046 |
Abstract: | Background: Orofacial clefts are one of the most common birth defects with multifactorial and only partly understood morphopathogenesis. Objective: The aim of this study was to evaluate the presence of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip. Methods: Lip mucosa tissue samples were obtained during surgical cleft correction from seven 2 to 6 months old children. Prepared tissue sections were stained by immunohistochemistry for TGF-β1, HGF, IGF-1 and IGF-1R. The intensity of staining was graded semiquantitatively. Results: We found numerous TGF-β1 and HGF-containing epithelial and connective tissue cells, moderate number of IGF-1 immunoreactive cells and even less pronounced presence of IGF-1R-positive cells. Conclusion: TGF-β1 and HGF are present in defective epithelia and soft tissue in cleft affected lip. Expressions of IGF-1 and IGF-1R show significant differences, and both factors play a role in the morphopathogenesis of clefts. |
Description: | Publisher Copyright: © 2017 Sidhom and Pilmane. |
DOI: | 10.2174/1874372201711010046 |
ISSN: | 1874-3722 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Detection_of_TGF_1.pdf | 398.28 kB | Adobe PDF | View/Open |
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