Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip

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dc.contributor.authorSidhom, Elga
dc.contributor.authorPilmane, Mara
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-04-22T13:40:02Z
dc.date.available2021-04-22T13:40:02Z
dc.date.issued2017-09-01
dc.descriptionPublisher Copyright: © 2017 Sidhom and Pilmane.
dc.description.abstractBackground: Orofacial clefts are one of the most common birth defects with multifactorial and only partly understood morphopathogenesis. Objective: The aim of this study was to evaluate the presence of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip. Methods: Lip mucosa tissue samples were obtained during surgical cleft correction from seven 2 to 6 months old children. Prepared tissue sections were stained by immunohistochemistry for TGF-β1, HGF, IGF-1 and IGF-1R. The intensity of staining was graded semiquantitatively. Results: We found numerous TGF-β1 and HGF-containing epithelial and connective tissue cells, moderate number of IGF-1 immunoreactive cells and even less pronounced presence of IGF-1R-positive cells. Conclusion: TGF-β1 and HGF are present in defective epithelia and soft tissue in cleft affected lip. Expressions of IGF-1 and IGF-1R show significant differences, and both factors play a role in the morphopathogenesis of clefts.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent407835
dc.identifier.citationSidhom, E & Pilmane, M 2017, 'Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip', Open Dermatology Journal, vol. 11, pp. 46-52. https://doi.org/10.2174/1874372201711010046
dc.identifier.doi10.2174/1874372201711010046
dc.identifier.issn1874-3722
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3907
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85032740544&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofOpen Dermatology Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCleft
dc.subjectHGF
dc.subjectIGF-1
dc.subjectIGF-1R
dc.subjectLip mucosa
dc.subjectOrofacial defects
dc.subjectTGF-β1
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectDermatology
dc.titleDetection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lipen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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