Please use this identifier to cite or link to this item:
10.1093/brain/awq281
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Stepens, Ainars | - |
dc.contributor.author | Stagg, Charlotte Jane | - |
dc.contributor.author | Platkajis, Ardis | - |
dc.contributor.author | Boudrias, Marie Hélène | - |
dc.contributor.author | Johansen-Berg, Heidi | - |
dc.contributor.author | Donaghy, Michael | - |
dc.date.accessioned | 2021-04-22T12:40:01Z | - |
dc.date.available | 2021-04-22T12:40:01Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | Stepens , A , Stagg , C J , Platkajis , A , Boudrias , M H , Johansen-Berg , H & Donaghy , M 2010 , ' White matter abnormalities in methcathinone abusers with an extrapyramidal syndrome ' , Brain , vol. 133 , no. 12 , pp. 3676-3684 . https://doi.org/10.1093/brain/awq281 | - |
dc.identifier.issn | 0006-8950 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3903 | - |
dc.description | Funding Information: National Institute for Health Research Oxford Biomedical Research Centre (to H.J.B. and C.J.S.); the Wellcome Trust (to H.J.B.) and the European Social Fund (to A.S.). Copyright: Copyright 2017 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | We examined white matter abnormalities in patients with a distinctive extrapyramidal syndrome due to intravenous methcathinone (ephedrone) abuse. We performed diffusion tensor imaging in 10 patients and 15 age-matched controls to assess white matter structure across the whole brain. Diffuse significant decreases in white matter fractional anisotropy, a diffusion tensor imaging metric reflecting microstructural integrity, occurred in patients compared with controls. In addition, we identified two foci of severe white matter abnormality underlying the right ventral premotor cortex and the medial frontal cortex, two cortical regions involved in higher-level executive control of motor function. Paths connecting different cortical regions with the globus pallidus, the nucleus previously shown to be abnormal on structural imaging in these patients, were generated using probabilistic tractography. The fractional anisotropy within all these tracts was lower in the patient group than in controls. Finally, we tested for a relationship between white matter integrity and clinical outcome. We identified a region within the left corticospinal tract in which lower fractional anisotropy was associated with greater functional deficit, but this region did not show reduced fractional anisotropy in the overall patient group compared to controls. These patients have widespread white matter damage with greatest severity of damage underlying executive motor areas. | en |
dc.format.extent | 9 | - |
dc.format.extent | 435560 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Brain | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | diffusion imaging | - |
dc.subject | extrapyramidal syndrome | - |
dc.subject | manganese toxicity | - |
dc.subject | methcathinone | - |
dc.subject | white matter tracts | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Clinical Neurology | - |
dc.title | White matter abnormalities in methcathinone abusers with an extrapyramidal syndrome | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1093/brain/awq281 | - |
dc.contributor.institution | Department of Neurology and Neurosurgery | - |
dc.contributor.institution | Department of Radiology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=78649888123&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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White_matter_abnormalities_in_methcathinone.pdf | 425.35 kB | Adobe PDF | View/Open![]() |
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