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Title: HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia
Authors: Stanevicha, Valda
Eglite, Jelena
Zavadska, Dace
Sochnevs, Arturs
Lazareva, Arina
Guseinova, Dinara
Shantere, Ruta
Gardovska, Dace
Department of Paediatrics
Joint Laboratory of Clinical Immunology and Immunogenetics
Keywords: Pediatrics, Perinatology, and Child Health;Rheumatology;Immunology and Allergy;3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database
Issue Date: 14-Oct-2010
Citation: Stanevicha , V , Eglite , J , Zavadska , D , Sochnevs , A , Lazareva , A , Guseinova , D , Shantere , R & Gardovska , D 2010 , ' HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia ' , Pediatric Rheumatology , vol. 8 , 26 .
Abstract: Objective: to investigate HLA B27 positive JIA patients clinical characteristics, determined HLA B27 allele types and their connection with antirheumatic treatment in homogenous patient groups.Materials and methods: 56 patients diagnosed with JIA and observed over the period 2006 to 2009 included in the study. HLAB27 allele types were determined using PCR method.Results: In HLA B27 positive JIA patients mean disease onset was 12.34 ± 3.3 years. Most common (44%) JIA type was enthesitis related arthritis. Positive response to the treatment with SS was found in 32% of patients, Methotrexate (MTX) - in 43%, combined treatment - SS with MTX was effective in 12.5%. 12.5% of patients required combination MTX with Enbrel.Eight HLA B27 allele types were found in JIA patients in Latvia: *2702, *2703, *2704, *2705, *2710, *2715, *2717, *2728. The most common was *2705 - in 55% of cases. Among all the patients enthesitis related arthritis most commonly occurred in patients with HLAB*2705 allele (OR = 2.01, p < 0.02), oligoarthritis in patients with *2710 allele (OR = 3.0, p < 0.04) and polyarthritis with *2717 allele (OR = 3.0, p < 0.05). In patients with *2705 allele effective treatment was MTX (OR = 1.13, p < 0.03) and MTX with SS (OR = 2.02, p < 0.05), but in patients having *2703 allele - MTX with Enbrel (OR = 2.94, p < 0.02).Conclusions: There are 8 different HLA B27 alleles in JIA patients in Latvia and the most common is *2705, but in order to assert them to be disease associated alleles, more extensive studies are needed, including control group of HLA B27 positive healthy individuals. Standard treatment approach with SS proves to be unsatisfactory in the majority of JIA patients. To improve children's quality of life achieving rapid disease control, the first line treatment in HLA B27 positive patients should be MTX. In order to start with the most appropriate drug it is necessary to determine HLAB 27 type at the onset of disease.
Description: Copyright: Copyright 2010 Elsevier B.V., All rights reserved.
ISSN: 1546-0096
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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