Please use this identifier to cite or link to this item:
10.3390/medicina47100075
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DC Field | Value | Language |
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dc.contributor.author | Nora-Krukle, Zaiga | - |
dc.contributor.author | Chapenko, Svetlana | - |
dc.contributor.author | Logina, Inara | - |
dc.contributor.author | Millers, Andrejs | - |
dc.contributor.author | Platkajis, Ardis | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2021-04-22T11:55:01Z | - |
dc.date.available | 2021-04-22T11:55:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Nora-Krukle , Z , Chapenko , S , Logina , I , Millers , A , Platkajis , A & Murovska , M 2011 , ' Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis ' , Medicina , vol. 47 , no. 10 , pp. 527-531 . https://doi.org/10.3390/medicina47100075 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3900 | - |
dc.description | Copyright: Copyright 2020 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Recent studies have focused on the associations between human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7), and multiple sclerosis (MS). The aim of this study was to investigate the associations between HHV-6 and HHV-7 reactivation and MS disease activity, and interleukin 12 (IL-12) and tumor necrosis factor α (TNF-α) production. Material and Methods. The frequency of plasma viremia by nested polymerase chain reaction and transcription of viral mRNA in peripheral blood mononuclear cells by reverse transcriptasepolymerase chain reaction (RT-PCR) of 14 relapsing/remitting (RR) and 14 secondary progressive (SP) MS patients were studied in comparison with clinical manifestation of the disease. Serum concentrations of cytokines IL-12 and TNF-α were analyzed by enzyme-linked immunosorbent assay. Results. Plasma samples from 25 of the 28 MS patients with estimated latent/persistent HHV-6 and/or HHV-7 infection were examined during relapse and remission/relative remission. HHV-6 reactivation was found in 4 of the 7 RRMS and 4 of the 7 SPMS patients, and HHV-7 reactivation was identified in 3 of the 7 RRMS and 1 of the 7 SPMS patients (all in relapse). In 2 of the 3 RRMS patients without viremia in relapse, HHV-6 mRNA transcription was detected. In RRMS and SPMS patients with active HHV-6 and HHV-7 infection in relapse, the serum concentrations of IL-12 and TNF-α were significantly higher than in those with latent virus infection. Conclusions. HHV-6 and HHV-7 reactivation could be implicated in the exacerbation of MS via activation of Th1 lymphocyte subsets. | en |
dc.format.extent | 5 | - |
dc.format.extent | 120629 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Medicina | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Human herpesvirus 6 | - |
dc.subject | Human herpesvirus 7 | - |
dc.subject | Interleukin 12 | - |
dc.subject | Multiple sclerosis | - |
dc.subject | Plasma viremia | - |
dc.subject | Tumor necrosis factor α | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.6 Biological sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/medicina47100075 | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.contributor.institution | Department of Neurology and Neurosurgery | - |
dc.contributor.institution | Department of Radiology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84856635738&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Human_Herpesvirus_6_and_7_Reactivation_and_Disease.pdf | 117.8 kB | Adobe PDF | View/Open |
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