Please use this identifier to cite or link to this item:
10.3390/medicina47100075
Title: | Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis |
Authors: | Nora-Krukle, Zaiga Chapenko, Svetlana Logina, Inara Millers, Andrejs Platkajis, Ardis Murovska, Modra Institute of Microbiology and Virology Department of Neurology and Neurosurgery Department of Radiology |
Keywords: | Human herpesvirus 6;Human herpesvirus 7;Interleukin 12;Multiple sclerosis;Plasma viremia;Tumor necrosis factor α;3.1 Basic medicine;1.6 Biological sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine;SDG 3 - Good Health and Well-being |
Issue Date: | 2011 |
Citation: | Nora-Krukle , Z , Chapenko , S , Logina , I , Millers , A , Platkajis , A & Murovska , M 2011 , ' Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis ' , Medicina , vol. 47 , no. 10 , pp. 527-531 . https://doi.org/10.3390/medicina47100075 |
Abstract: | Recent studies have focused on the associations between human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7), and multiple sclerosis (MS). The aim of this study was to investigate the associations between HHV-6 and HHV-7 reactivation and MS disease activity, and interleukin 12 (IL-12) and tumor necrosis factor α (TNF-α) production. Material and Methods. The frequency of plasma viremia by nested polymerase chain reaction and transcription of viral mRNA in peripheral blood mononuclear cells by reverse transcriptasepolymerase chain reaction (RT-PCR) of 14 relapsing/remitting (RR) and 14 secondary progressive (SP) MS patients were studied in comparison with clinical manifestation of the disease. Serum concentrations of cytokines IL-12 and TNF-α were analyzed by enzyme-linked immunosorbent assay. Results. Plasma samples from 25 of the 28 MS patients with estimated latent/persistent HHV-6 and/or HHV-7 infection were examined during relapse and remission/relative remission. HHV-6 reactivation was found in 4 of the 7 RRMS and 4 of the 7 SPMS patients, and HHV-7 reactivation was identified in 3 of the 7 RRMS and 1 of the 7 SPMS patients (all in relapse). In 2 of the 3 RRMS patients without viremia in relapse, HHV-6 mRNA transcription was detected. In RRMS and SPMS patients with active HHV-6 and HHV-7 infection in relapse, the serum concentrations of IL-12 and TNF-α were significantly higher than in those with latent virus infection. Conclusions. HHV-6 and HHV-7 reactivation could be implicated in the exacerbation of MS via activation of Th1 lymphocyte subsets. |
Description: | Copyright: Copyright 2020 Elsevier B.V., All rights reserved. |
DOI: | 10.3390/medicina47100075 |
ISSN: | 1010-660X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Human_Herpesvirus_6_and_7_Reactivation_and_Disease.pdf | 117.8 kB | Adobe PDF | View/Open |
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