Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis

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dc.contributor.authorNora-Krukle, Zaiga
dc.contributor.authorChapenko, Svetlana
dc.contributor.authorLogina, Inara
dc.contributor.authorMillers, Andrejs
dc.contributor.authorPlatkajis, Ardis
dc.contributor.authorMurovska, Modra
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.contributor.institutionDepartment of Radiology
dc.date.accessioned2021-04-22T11:55:01Z
dc.date.available2021-04-22T11:55:01Z
dc.date.issued2011
dc.descriptionCopyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractRecent studies have focused on the associations between human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7), and multiple sclerosis (MS). The aim of this study was to investigate the associations between HHV-6 and HHV-7 reactivation and MS disease activity, and interleukin 12 (IL-12) and tumor necrosis factor α (TNF-α) production. Material and Methods. The frequency of plasma viremia by nested polymerase chain reaction and transcription of viral mRNA in peripheral blood mononuclear cells by reverse transcriptasepolymerase chain reaction (RT-PCR) of 14 relapsing/remitting (RR) and 14 secondary progressive (SP) MS patients were studied in comparison with clinical manifestation of the disease. Serum concentrations of cytokines IL-12 and TNF-α were analyzed by enzyme-linked immunosorbent assay. Results. Plasma samples from 25 of the 28 MS patients with estimated latent/persistent HHV-6 and/or HHV-7 infection were examined during relapse and remission/relative remission. HHV-6 reactivation was found in 4 of the 7 RRMS and 4 of the 7 SPMS patients, and HHV-7 reactivation was identified in 3 of the 7 RRMS and 1 of the 7 SPMS patients (all in relapse). In 2 of the 3 RRMS patients without viremia in relapse, HHV-6 mRNA transcription was detected. In RRMS and SPMS patients with active HHV-6 and HHV-7 infection in relapse, the serum concentrations of IL-12 and TNF-α were significantly higher than in those with latent virus infection. Conclusions. HHV-6 and HHV-7 reactivation could be implicated in the exacerbation of MS via activation of Th1 lymphocyte subsets.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent120629
dc.identifier.citationNora-Krukle, Z, Chapenko, S, Logina, I, Millers, A, Platkajis, A & Murovska, M 2011, 'Human herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosis', Medicina, vol. 47, no. 10, pp. 527-531. https://doi.org/10.3390/medicina47100075
dc.identifier.doi10.3390/medicina47100075
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3900
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84856635738&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHuman herpesvirus 6
dc.subjectHuman herpesvirus 7
dc.subjectInterleukin 12
dc.subjectMultiple sclerosis
dc.subjectPlasma viremia
dc.subjectTumor necrosis factor α
dc.subject3.1 Basic medicine
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHuman herpesvirus 6 and 7 reactivation and disease activity in multiple sclerosisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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