Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0034
| Title: | Immunogenetic Manifestations of Lyme Borreliosis |
| Authors: | Kovačuka, Lilija Eglīte, Jeļena Zālīte, Māra Lucenko, Irina Vīksna, Ludmila Krūmiņa, Angelika Joint Laboratory of Clinical Immunology and Immunogenetics Department of Infectology |
| Keywords: | HLA alleles;Lyme borreliosis;PCR-SSP;1.6 Biological sciences;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General;SDG 3 - Good Health and Well-being |
| Issue Date: | 1-Aug-2016 |
| Citation: | Kovačuka , L , Eglīte , J , Zālīte , M , Lucenko , I , Vīksna , L & Krūmiņa , A 2016 , ' Immunogenetic Manifestations of Lyme Borreliosis ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 215-219 . https://doi.org/10.1515/prolas-2016-0034 |
| Abstract: | In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group. |
| Description: | Publisher Copyright: © 2016 by Lilija Kovačuka. Copyright: Copyright 2016 Elsevier B.V., All rights reserved. |
| DOI: | 10.1515/prolas-2016-0034 |
| ISSN: | 1407-009X |
| Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| Immunogenetic_Manifestations_of_Lyme_Borreliosis.pdf | 76.7 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.