Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0032
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DC Field | Value | Language |
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dc.contributor.author | Capenko, Svetlana | - |
dc.contributor.author | Mihailova, Marija | - |
dc.contributor.author | Rasa, Santa | - |
dc.contributor.author | Krūminą, Angelika | - |
dc.contributor.author | Zazerska, Zane | - |
dc.contributor.author | Logina, Inara | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2021-04-20T13:40:01Z | - |
dc.date.available | 2021-04-20T13:40:01Z | - |
dc.date.issued | 2016-08-01 | - |
dc.identifier.citation | Capenko , S , Mihailova , M , Rasa , S , Krūminą , A , Zazerska , Z , Logina , I & Murovska , M 2016 , ' Possible Relation of Roseolovirus Infection with Fibromyalgia ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 205-210 . https://doi.org/10.1515/prolas-2016-0032 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3873 | - |
dc.description | Publisher Copyright: © 2016 by Svetlana Capenko. Copyright: Copyright 2016 Elsevier B.V., All rights reserved. | - |
dc.description.abstract | Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and-7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses potentially pathogenic to the nervous system. Presence of anti-HHV-6 and-HHV-7 antibodies and viral genomic sequences, viral loads, HHV-6 variant-specificity, and TNF-α level were studied in 41 FM patients and 50 healthy individuals using polymerase chain reactions, restriction endonuclease analysis and ELISA. There was no difference in the presence of anti-HHV-6 and anti-HHV-7 IgG class antibodies between FM patients and control group individuals. Viral sequences were found in 80.5% of FM patients and in 62.0% of controls. Significantly higher rate of concurrent HHV-6 and HHV-7 infection and higher viral loads in peripheral blood were detected in FM patients compared to the control group individuals. Plasma viremia was detected only in FM patients. Significantly higher TNF-α levels were detected in virus positive FM patients. From all positive cases only in two FM patients HHV-6A was revealed. Significantly higher detection frequency of concurrent HHV-6 and HHV-7 infection, simultaneous HHV-6 and HHV-7 activation, higher viral loads and TNF-α expression levels in primary FM patients than in control group individuals indicate the potential involvement of Roseoloviruses in development of this disorder. | en |
dc.format.extent | 6 | - |
dc.format.extent | 85455 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | fibromyalgia | - |
dc.subject | human herpesvirus-6 | - |
dc.subject | human herpesvirus-7 | - |
dc.subject | infection | - |
dc.subject | molecular diagnostic | - |
dc.subject | 3.3 Health sciences | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Possible Relation of Roseolovirus Infection with Fibromyalgia | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1515/prolas-2016-0032 | - |
dc.contributor.institution | Department of Neurology and Neurosurgery | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.contributor.institution | Department of Infectology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84983456649&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Possible_Relation_of_Roseolovirus_Infection_with_Fibromyalgia.pdf | 83.45 kB | Adobe PDF | View/Open |
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