Please use this identifier to cite or link to this item:
10.2478/prolas-2019-0059
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DC Field | Value | Language |
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dc.contributor.author | Zviedre, Astra | - |
dc.contributor.author | Eņgelis, Arnis | - |
dc.contributor.author | Tretjakovs, Peteris | - |
dc.contributor.author | Zile, Irisa | - |
dc.contributor.author | Petersons, Aigars | - |
dc.date.accessioned | 2021-04-20T13:25:03Z | - |
dc.date.available | 2021-04-20T13:25:03Z | - |
dc.date.issued | 2019-08-01 | - |
dc.identifier.citation | Zviedre , A , Eņgelis , A , Tretjakovs , P , Zile , I & Petersons , A 2019 , ' Laboratory Tests in Addition to the Alvarado Score in the Management of Acute Appendicitis in School-Age Children ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 73 , no. 4 , pp. 379-386 . https://doi.org/10.2478/prolas-2019-0059 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/3872 | - |
dc.description | Funding Information: The study was financially supported by a Grant No. 2010.10-4/VPP-4 of the framework of the Latvian National Programme and Grant No. 2009/0147/1DP/1.1.2.1.2/09/ IPIA/VIAA/009 from the project Support for Doctoral and Post-doctoral Investigations Rîga Stradiòð University fellowship. Publisher Copyright: © 2019 Astra Zviedre et al., published by Sciendo 2019. | - |
dc.description.abstract | The aim of the study was to determine whether the Alvarado score (AS) together with laboratory tests could be used to distinguish patients with acute appendicitis (AA) from acute mesenteric lymphadenitis (AML). Fifty-seven patients (7-18 years) with suspected AA were included in the prospective study (October 2010 - October 2013). Thirty-one patients underwent surgery for AA and 26 were not treated surgically and were diagnosed AML on ultrasonography. AS, white blood cell count (WBC), C - reactive protein (CRP) and serum cytokines (EGF, IL-10, IL-12(p70), IL-1β, IL-4, IL-6, IL-8, IL-17, MCP-1, TNF-α) were obtained on admission and were compared between groups. Mean age of the 57 patients was 12.9 (SD 3.2). Accuracy (AR) for AS ≥ 7 alone was 73.7% for AA. Modified AS with certain serum cytokines seemed to be a reliable tool for initial differential diagnosis between AA and AML in school-age children. Based on these results, AS ≥ 7, WBC ≥ 10.7 × 103/μL and serum IL-6 ≥ 4.3 pg/mL assessed altogether will yield more sensitivity for AA. Also for further advanced diagnostics, we propose to take into account the serum IL-6, IL-8, MCP-1, CRP cut-off levels in the differential diagnosis between complicated and uncomplicated AA to decide whether the treatment should be conservative or surgical. | en |
dc.format.extent | 8 | - |
dc.format.extent | 553028 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Alvarado score | - |
dc.subject | appendicitis | - |
dc.subject | mesenteric lymphadenitis | - |
dc.subject | serum cytokines | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.title | Laboratory Tests in Addition to the Alvarado Score in the Management of Acute Appendicitis in School-Age Children | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2478/prolas-2019-0059 | - |
dc.contributor.institution | Department of Paediatric Surgery | - |
dc.contributor.institution | Department of Human Physiology and Biochemistry | - |
dc.contributor.institution | Department of Public Health and Epidemiology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85069684925&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Laboratory_Tests_in_Addition_to_the_Alvarado_Score.pdf | 540.07 kB | Adobe PDF | View/Open![]() |
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