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Title: Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis
Authors: Kovalchuka, Lilija
Cvetkova, Svetlana
Trofimova, Julija
Eglite, Jelena
Gintere, Sandra
Lucenko, Irina
Oczko-Grzesik, Barbara
Viksna, Ludmila
Krumina, Angelika
Joint Laboratory of Clinical Immunology and Immunogenetics
Department of Family Medicine
Department of Infectology
Keywords: Borrelia burgdorferi;HLA-DRB1;Immunogenetic markers;Lyme borreliosis;Lyme neuroborreliosis;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Public Health, Environmental and Occupational Health;Health, Toxicology and Mutagenesis
Issue Date: 1-Dec-2016
Citation: Kovalchuka , L , Cvetkova , S , Trofimova , J , Eglite , J , Gintere , S , Lucenko , I , Oczko-Grzesik , B , Viksna , L & Krumina , A 2016 , ' Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis ' , International Journal of Environmental Research and Public Health , vol. 13 , no. 12 , 1194 .
Abstract: The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.
Description: Funding Information: This work was supported by the European Social Fund (ESF) project ?Support for doctoral study program and scientific degree receiving in Riga Stradi?? University, agreement No. 2009/0147/1DP/ Publisher Copyright: © 2016 by the authors; licensee MDPI, Basel, Switzerland. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
ISSN: 1661-7827
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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